Li Xue, Tan Chin-Ping, Liu Yuan-Fa, Xu Yong-Jiang
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Food, National Engineering Laboratory for Cereal Fermentation Technology, Collaborative Innovation Center of Food Safety and Quality Control, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, People's Republic of China.
Department of Food Technology, Faculty of Food Science and Technology, University Putra Malaysia, Selangor 410500, Malaysia.
J Agric Food Chem. 2020 Dec 16;68(50):14728-14738. doi: 10.1021/acs.jafc.0c07378. Epub 2020 Dec 8.
The intestine is an important digestive organ of the human body, and its barrier is the guardian of the body from the external environment. The impairment of the intestinal barrier is believed to be an important determinant in various foodborne diseases. Food hazards can lead to the occurrence of many foodborne diseases represented by inflammation. Therefore, understanding the mechanisms of the impact of the food hazards on intestinal barriers is essential for promoting human health. This review examined the relationship between food hazards and the intestinal barrier in three aspects: apoptosis, imbalance of gut microbiota, and pro-inflammatory cytokines. The mechanism of dysfunctional gut microbiota caused by food hazards was also discussed. This review discusses the interaction among food hazards, intestinal barrier, and foodborne diseases and, thus, offers a new thought to deal with foodborne disease.
肠道是人体重要的消化器官，其屏障是人体抵御外部环境的守护者。肠道屏障受损被认为是各种食源性疾病的重要决定因素。食物危害可导致以炎症为代表的多种食源性疾病的发生。因此，了解食物危害对肠道屏障的影响机制对于促进人类健康至关重要。本综述从细胞凋亡、肠道微生物群失衡和促炎细胞因子三个方面探讨了食物危害与肠道屏障之间的关系。还讨论了食物危害导致肠道微生物群功能失调的机制。本综述探讨了食物危害、肠道屏障和食源性疾病之间的相互作用，从而为应对食源性疾病提供了新的思路。
