Pharmacy College, Taishan Medical University , Taian 271016 , China.
Org Lett. 2018 Jul 6;20(13):4005-4009. doi: 10.1021/acs.orglett.8b01395. Epub 2018 Jun 26.
A regioselective green approach for the nickel(II)-catalyzed C-N cross-coupling between arylamines and pyrazoles through a photoredox process is reported. Moderate to good yield was observed for this reaction, performed in water under air at room temperature. This strategy provides a powerful tool for the green synthesis of pyrazole-containing bioactive molecules. In addition, a single-electron-transfer mechanism is proposed in this report.
本文报道了一种通过光氧化还原过程实现芳胺和吡唑之间镍(II)催化 C-N 交叉偶联的区域选择性绿色方法。在空气存在下，室温下在水中进行该反应，可获得中等至良好的产率。该策略为含吡唑的生物活性分子的绿色合成提供了有力工具。此外，本报告还提出了单电子转移机制。
