Shinohara K, Fujiki H, Hidaka Y, Tseng Y K, Murakami H, Omura H
Acta Vitaminol Enzymol. 1985;7(1-2):99-108.
The effect of some reductones such as ascorbic acid (AsA), triose reductone (TR), epinephrine (Ep) and their derivatives on cyclic 3', 5'-adenosine monophosphate phosphodiesterase (cAMP PDE) was studied in the presence or absence of Cu2+. AsA, TR, Ep and the reductones related to them inhibited cAMP PDE activity. Among the reductones, TR showed the highest inhibition. AsA, 5-methyl-3,4-dihydroxytetrone, pyrocatechol, p-hydroxyquinone and resorcinol had a relatively high inhibiting activity. The type of inhibition of AsA, TR and Ep was uncompetitive, competitive and noncompetitive, respectively. Cu2+ enhanced the inhibitory action of the reductones markedly and altered the type of inhibition of the reductones.
在有或没有Cu2+存在的情况下，研究了一些还原酮如抗坏血酸（AsA）、丙糖还原酮（TR）、肾上腺素（Ep）及其衍生物对环3'，5'-腺苷单磷酸磷酸二酯酶（cAMP PDE）的影响。AsA、TR、Ep及其相关还原酮抑制cAMP PDE活性。在这些还原酮中，TR的抑制作用最强。AsA、5-甲基-3,4-二羟基四酮、邻苯二酚、对苯二酚和间苯二酚具有相对较高的抑制活性。AsA、TR和Ep的抑制类型分别为非竞争性、竞争性和非竞争性。Cu2+显著增强了还原酮的抑制作用，并改变了还原酮的抑制类型。
