伊巴丹造血系统肿瘤性疾病：一项前瞻性研究的初步报告。

Neoplastic diseases of the haemopoietic system in Ibadan: preliminary report of a prospective study.

作者信息

Williams C K

出版信息

Afr J Med Med Sci. 1985 Mar-Jun;14(1-2):89-94.

Abstract

The clinical and epidemiological features of haemopoietic malignancies in Ibadan have been evaluated in this preliminary analysis on findings on 113 patients seen at the University College Hospital, Ibadan, Nigeria, from July 1978 to June 1981. Twenty-seven patients had acute myelogenous (AML), twenty-two acute lymphoblastic (ALL), thirty-one chronic myelocytic (AML), thirty-one chronic lymphocytic leukaemia (CLL), two had polycythaemia rubra vera (PRV) and one myelofibrosis (MF). Incidence rates (IR) of 0.9 X 10(-5) and 1.9 X 10(-5) were estimated for acute leukemia (AL) and all leukemia subtypes respectively. Chloroma occurred frequently in association with AML especially in childhood, and CLL in elderly patients (greater than 50 years) and ALL appeared to manifest unusually aggressive features in spite of apparently adequate chemotherapy. Some of these clinical and epidemiological features suggest deviant biology of some haemopoietic malignancies in Ibadan.

摘要

在这项初步分析中，对1978年7月至1981年6月期间在尼日利亚伊巴丹大学学院医院就诊的113例患者的研究结果进行了评估，以了解伊巴丹造血系统恶性肿瘤的临床和流行病学特征。27例患者患有急性髓细胞白血病（AML），22例患有急性淋巴细胞白血病（ALL），31例患有慢性粒细胞白血病（CML），31例患有慢性淋巴细胞白血病（CLL），2例患有真性红细胞增多症（PRV），1例患有骨髓纤维化（MF）。急性白血病（AL）和所有白血病亚型的发病率（IR）分别估计为0.9×10⁻⁵和1.9×10⁻⁵。绿色瘤常与AML相关，尤其是在儿童期，CLL多见于老年患者（大于50岁），而ALL尽管接受了明显充分的化疗，仍表现出异常侵袭性的特征。这些临床和流行病学特征中的一些表明伊巴丹某些造血系统恶性肿瘤的生物学特性存在异常。