Williams Christopher Ko, Foroni Letizia, Luzzatto Lucio, Saliu Idris, Levine Arthur, Greaves Mel F
Department of Haematology, College of Medicine, University of Ibadan, Ibadan, Nigeria ; Hematology Oncology Consultancy, Port Angeles, WA 98362, USA ; FHCRC/UW Centre for AIDS Research (CFAR), Seattle, WA 98104, USA.
Department of Haematology, Royal Postgraduate Medicine School, London W12 ONN, England.
Ecancermedicalscience. 2014 Nov 6;8:478. doi: 10.3332/ecancer.2014.478. eCollection 2014.
Major differences exist in the nature of leukaemia and lymphoma in low-income African children compared to those in the high-income countries. These include the absence of the peak incidence of acute lymphoblastic leukaemia (ALL) in under-five-year olds that characterizes the disease in high-income countries. Conversely, chloroma association with acute myelogenous leukaemia (CA-AML/AMML) and Burkitt's lymphoma (BL) are rare in the high-income countries. This report describes clinical and laboratory as well as epidemiological features of childhood leukaemia and lymphoma reported betwen 1982 and 1984 in the city of Ibadan, Nigeria. The observed pattern of distribution of childhood haematological malignancies in the city is more consistent with the observations of Ludwik Gross's experiments on environmental influences, such as malnutrition and infections, animal leukaemogenesis, and mirroring the consequences of the primordial pressures that have shaped human genetics and pathophysiology.
与高收入国家的儿童相比，低收入非洲儿童白血病和淋巴瘤的性质存在重大差异。这些差异包括，五岁以下儿童急性淋巴细胞白血病（ALL）高发的情况在低收入非洲儿童中并不存在，而这一高发特征是高收入国家该疾病的特点。相反，绿色瘤合并急性髓性白血病（CA-AML/AMML）和伯基特淋巴瘤（BL）在高收入国家较为罕见。本报告描述了1982年至1984年期间在尼日利亚伊巴丹市报告的儿童白血病和淋巴瘤的临床、实验室及流行病学特征。在该市观察到的儿童血液系统恶性肿瘤的分布模式，与卢德维克·格罗斯关于环境影响（如营养不良和感染）、动物白血病发生的实验结果更为一致，并且反映了塑造人类遗传学和病理生理学的原始压力的后果。
