Uchida K, Jikko A, Yamato T, Kamiyama Y, Ozawa K
Am J Med Sci. 1985 Jul;290(1):19-27. doi: 10.1097/00000441-198507000-00005.
The relationship of glucose intolerance and indocyanine green clearance to respiratory enzyme levels in liver mitochondria was studied along with standard liver function tests in 40 patients (8 cirrhosis, 19 cirrhosis with hepatoma, 13 non-cirrhotic with hepatoma). There was a negative correlation between cytochrome a(+a3) concentrations and phosphorylative activity per unit of cytochrome a(+a3) (r = -0.75, p less than 0.01), but no correlation between ICG-K and cytochrome a(+a3) concentrations. Cytochrome a(+a3) concentrations in cirrhotic patients with linear oral glucose tolerance pattern, characterized with no return toward normal glucose levels within 120 minutes after an oral glucose load, increased to 1.45 +/- 0.11 (10(-10) mol/mg of protein) compared with 0.90 +/- 0.07 in cirrhotic patients with parabolic OGTT pattern, characterized with a return toward normal glucose levels within 120 minutes (p less than 0.01) (0.82 +/- 0.02 in control patients without liver diseases). The former had high operative mortality regardless of ICG-K value and the latter had virtually uneventful clinical courses. It was suggested that increased cytochrome a(+a3) concentrations and impaired glucose tolerance might be responsible for decreased hepatic functional reserve and poor prognosis in cirrhotics.
在40例患者（8例肝硬化、19例肝硬化合并肝癌、13例非肝硬化合并肝癌）中，研究了葡萄糖耐量异常和吲哚菁绿清除率与肝线粒体呼吸酶水平的关系，并进行了标准肝功能检查。细胞色素a（+a3）浓度与每单位细胞色素a（+a3）的磷酸化活性之间呈负相关（r = -0.75，p < 0.01），但吲哚菁绿清除率（ICG-K）与细胞色素a（+a3）浓度之间无相关性。口服葡萄糖耐量呈线性模式的肝硬化患者，即在口服葡萄糖负荷后120分钟内血糖水平未恢复正常，其细胞色素a（+a3）浓度升至1.45±0.11（10⁻¹⁰mol/mg蛋白质），而口服葡萄糖耐量呈抛物线型模式的肝硬化患者，即在120分钟内血糖水平恢复正常，其细胞色素a（+a3）浓度为0.90±0.07（p < 0.01）（无肝脏疾病的对照患者为0.82±0.02）。前者无论ICG-K值如何，手术死亡率均较高，而后者临床过程基本平稳。提示细胞色素a（+a3）浓度升高和葡萄糖耐量受损可能是肝硬化患者肝功能储备下降和预后不良的原因。
