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融合技术与腰椎间盘突出症再次手术风险较低相关:台湾全国队列的5年观察研究

Fusion Techniques Are Related to a Lower Risk of Reoperation in Lumbar Disc Herniation: A 5-Year Observation Study of a Nationwide Cohort in Taiwan.

作者信息

Cheng Chun-Yu, Cheng Ya-Chung, Wang Ting-Chung, Yang Wei-Hsun

机构信息

Department of Neurosurgery, Chang Gung Memorial Hospital, Chiayi, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Neurosurgery, University of Washington, Seattle, Washington, USA.

Department of Internal medicine, College of Medicine, Nation Taiwan University, Taiwan.

出版信息

World Neurosurg. 2018 Sep;117:e660-e668. doi: 10.1016/j.wneu.2018.06.109. Epub 2018 Jun 23.

Abstract

OBJECTIVE

Lumbar disc herniation (LDH) is a common spinal problem, with reoperation rates of 6%-24%. Although different surgical techniques are used for treatment, there is still debate regarding whether fusion techniques can reduce the reoperation rate in patients with LDH.

METHODS

This retrospective study used a 5-year nationwide database to analyze reoperation rates in Taiwan. Patient age groups (≥20 and <90 years) treated by index surgery and reoperation for LDH were identified. Four surgical procedures were included in the analysis: discectomy (DC), anterior lumbar fusion with DC (FA + DC), posterior lumbar fusion (FP), and posterior lumbar fusion with DC (FP + DC).

RESULTS

There were 1743 index surgeries between 2008 and 2012, with 184 (10.56%) reoperations. Index surgery DC had the highest reoperation rate (n = 121, 20%). The reoperation risk was significantly lower for patients undergoing fusion procedures (FA + DC vs. DC [hazard ratio (HR), 0.24; 95% confidence interval (CI), 0.12-0.47; P < 0.01], FP versus DC [HR, 0.17; 95% C, 0.09-0.33; P <0.01], FP + DC versus DC [HR, 0.31; 95% CI, 0.22-0.44; P < 0.01]). Fusion procedures had significantly higher treatment costs compared with DC (FA + DC vs. FP vs. FP + DC vs. DC: 5851.74 ± 4808.94 vs. 5116.88 ± 3428.97 vs. 4782.16 ± 2902.19 vs. 3846.79 ± 3584.45 U.S. dollars/patient, respectively; P < 0.0001).

CONCLUSIONS

Among surgical procedures for LDH, fusion techniques are related to lower reoperation rates compared with discectomy, but at the expense of higher medical costs.

摘要

目的

腰椎间盘突出症(LDH)是一种常见的脊柱疾病,再次手术率为6%-24%。尽管采用了不同的手术技术进行治疗,但关于融合技术是否能降低LDH患者的再次手术率仍存在争议。

方法

这项回顾性研究使用了一个为期5年的全国性数据库来分析台湾地区的再次手术率。确定了接受初次手术和因LDH进行再次手术的患者年龄组(≥20岁和<90岁)。分析包括四种手术方式:椎间盘切除术(DC)、前路腰椎融合术联合DC(FA + DC)、后路腰椎融合术(FP)以及后路腰椎融合术联合DC(FP + DC)。

结果

2008年至2012年间有1743例初次手术,其中184例(10.56%)进行了再次手术。初次手术采用DC的再次手术率最高(n = 121,20%)。接受融合手术的患者再次手术风险显著更低(FA + DC与DC相比[风险比(HR),0.24;95%置信区间(CI),0.12 - 0.47;P < 0.01],FP与DC相比[HR,0.17;95% CI,0.09 - 0.33;P < 0.01],FP + DC与DC相比[HR,0.31;95% CI,0.22 - 0.44;P < 0.01])。与DC相比,融合手术的治疗成本显著更高(FA + DC与FP与FP + DC与DC相比:分别为5851.74 ± 4808.94美元/患者、5116.88 ± 3428.97美元/患者、4782.16 ± 2902.19美元/患者、3846.79 ± 3584.45美元/患者;P < 0.0001)。

结论

在LDH的手术方式中,与椎间盘切除术相比,融合技术与更低的再次手术率相关,但代价是更高的医疗成本。

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