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不同类型腰椎手术后的5年再次手术率。

5-year reoperation rates after different types of lumbar spine surgery.

作者信息

Malter A D, McNeney B, Loeser J D, Deyo R A

机构信息

Department of Health Services, University of Washington, Seattle, USA.

出版信息

Spine (Phila Pa 1976). 1998 Apr 1;23(7):814-20. doi: 10.1097/00007632-199804010-00015.

Abstract

STUDY DESIGN

Population-based cohort study of Washington State patients who underwent lumbar spine surgery for degenerative conditions in 1988.

OBJECTIVES

To compare complications and reoperation rates during the 5-year period after surgery between patients who have undergone lumbar spine fusion surgery and those who have undergone laminectomy or discectomy alone.

SUMMARY OF BACKGROUND DATA

Spinal fusion is associated with wider surgical exposure, more extensive dissection, and longer operative times than lumbar surgery without fusion, and previous studies have shown higher complication rates and hospital charges associated with these more complex procedures. In elderly patients, spinal fusion operations were associated with higher mortality rates than laminectomy or discectomy alone, and reoperation rates were not lower. In the current study, reoperations, mortality, and complications following lumbar spine surgery were examined for the general population.

METHODS

A statewide hospital discharge database was used to identify all Washington patients who underwent spine surgery in 1988 and to determine the rate of reoperation during the subsequent 5 years. Administrative records also were used to identify complications, mortality, and hospital charges associated with the operations. Unadjusted complication and reoperation rates for the groups were compared using chi-square statistics. Adjusted rates were compared using logistic regression and proportional hazards (Cox) regression after controlling for age, gender, prior spine surgery, diagnosis, comorbidity, type of surgery, and coverage by Workers' Compensation.

RESULTS

Of 6376 patients who underwent lumbar surgery for degenerative conditions in Washington in 1988, 1041 (16%) had operations involving spine fusion. Diagnoses of degenerative disc disease or possible instability were more frequent among patients undergoing fusion surgery, whereas herniated discs were more frequent among those undergoing discectomy or laminectomy alone. Complications were recorded in 18% of fusion patients and 7% of nonfusion patients (P < 0.01), but mortality rates did not differ. Unadjusted reoperation rates over the 5-year period were greater for patients who underwent fusion than for patients who underwent nonfusion surgery (18% vs. 15%, respectively), but after adjustment for baseline characteristics, fusion patients had only a slightly greater (and nonsignificant) risk of reoperation (relative risk 1.1, confidence interval .9-1.3).

CONCLUSION

As in previous studies, complications in the current study occurred more frequently among patients who underwent lumbar spine fusion than among those who underwent laminectomy or discectomy alone. Reoperations were at least as frequent after fusion, but the authors could not assess treatment efficacy in terms of pain relief or improved function. Although the characteristics of patients undergoing fusion differed from those undergoing a laminectomy or discectomy alone, there appeared to be sufficient overlap in the clinical populations to warrant closer scrutiny of the safety, efficacy, and indications for spinal fusions, preferably in randomized trials.

摘要

研究设计

对1988年因退行性疾病接受腰椎手术的华盛顿州患者进行基于人群的队列研究。

目的

比较接受腰椎融合手术的患者与仅接受椎板切除术或椎间盘切除术的患者在术后5年期间的并发症和再次手术率。

背景资料总结

与不进行融合的腰椎手术相比,脊柱融合术需要更广泛的手术暴露、更广泛的解剖分离以及更长的手术时间,先前的研究表明,这些更复杂的手术相关的并发症发生率和住院费用更高。在老年患者中,脊柱融合手术的死亡率高于单独的椎板切除术或椎间盘切除术,且再次手术率也不低。在本研究中,对普通人群腰椎手术后的再次手术、死亡率和并发症进行了检查。

方法

使用全州范围的医院出院数据库来识别1988年在华盛顿接受脊柱手术的所有患者,并确定随后5年的再次手术率。行政记录也用于识别与手术相关的并发症、死亡率和住院费用。使用卡方统计比较两组未经调整的并发症和再次手术率。在控制年龄、性别、既往脊柱手术史、诊断、合并症、手术类型和工人赔偿保险范围后,使用逻辑回归和比例风险(Cox)回归比较调整后的比率。

结果

1988年在华盛顿因退行性疾病接受腰椎手术的6376例患者中,1041例(16%)接受了涉及脊柱融合的手术。退行性椎间盘疾病或可能的不稳定诊断在接受融合手术的患者中更常见,而单纯椎间盘突出在接受椎间盘切除术或椎板切除术的患者中更常见。18%的融合患者和7%的非融合患者记录有并发症(P<0.01),但死亡率无差异。在5年期间,接受融合手术的患者未经调整的再次手术率高于接受非融合手术的患者(分别为18%和15%),但在对基线特征进行调整后,融合患者再次手术的风险仅略高(且无统计学意义)(相对风险1.1,置信区间0.9 - 1.3)。

结论

与先前的研究一样,本研究中接受腰椎融合手术的患者比仅接受椎板切除术或椎间盘切除术的患者并发症更频繁。融合术后再次手术至少同样频繁,但作者无法评估在缓解疼痛或改善功能方面的治疗效果。尽管接受融合手术的患者特征与仅接受椎板切除术或椎间盘切除术的患者不同,但临床人群中似乎有足够的重叠,值得对脊柱融合术的安全性、有效性和适应症进行更仔细的审查,最好在随机试验中进行。

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