Seitz W, Lübbe N, Bechstein W, Fritz K, Kirchner E
Anasth Intensivther Notfallmed. 1985 Jun;20(3):119-24.
The effects of halothane anaesthesia or epidural analgesia on the per- and postoperative change in blood concentrations of ACTH, beta-lipotropin, cortisol, dehydroepiandrosterone, aldosterone, glucose, lactate and free fatty acids were investigated in connection with elective orthopaedic surgery. Anaesthesia in man with halothane and nitrous oxide was found to be associated with a significant increase in plasma ACTH levels and beta-LPH levels. Changes in plasma dehydroepiandrosterone were similar to those in plasma cortisol. The elevation of plasma aldosterone during major surgery could be explained as the effect of an increased renin secretion. However, simultaneous increase in plasma cortisol and plasma aldosterone during surgery reflect an additional effect of adrenocorticotropin upon aldosterone secretion.
结合择期骨科手术，研究了氟烷麻醉或硬膜外镇痛对促肾上腺皮质激素（ACTH）、β-促脂素、皮质醇、脱氢表雄酮、醛固酮、葡萄糖、乳酸和游离脂肪酸血液浓度术前和术后变化的影响。发现人类使用氟烷和氧化亚氮麻醉与血浆促肾上腺皮质激素水平和β-促脂素水平显著升高有关。血浆脱氢表雄酮的变化与血浆皮质醇的变化相似。大手术期间血浆醛固酮升高可解释为肾素分泌增加的作用。然而，手术期间血浆皮质醇和血浆醛固酮同时增加反映了促肾上腺皮质激素对醛固酮分泌的额外作用。
