TMEPAI 家族：参与多种信号通路的调节。
TMEPAI family: involvement in regulation of multiple signalling pathways.
机构信息
Laboratory of Biochemistry, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo, Japan.
Laboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, Japan.
出版信息
J Biochem. 2018 Sep 1;164(3):195-204. doi: 10.1093/jb/mvy059.
The TMEPAI family, composed of TMEPAI and C18ORF1, is known to inhibit transforming growth factor-β (TGF-β) signalling via its competition for binding of receptor-regulated Smad with Smad anchor for receptor activation. However, TMEPAI has also been reported to be involved in androgen receptor signalling, phosphatase and tensin homologue deleted on chromosome 10 signalling, and formation of autophagosomes in addition to degradation of TβRI (TGF-β type I receptor) through lysosomes. Thus, TMEPAI seems to act as a regulator of multiple signalling pathways. A great deal of attention has already been paid to the relationship between the TMEPAI family and tumourigenicity. In this paper, therefore, we describe recent progresses in the understanding of how the TMEPAI family physiologically contributes to cellular functions and diseases.
TMEPAI 家族由 TMEPAI 和 C18ORF1 组成，已知通过与其竞争受体调节性 Smad 与 Smad 受体激活锚定物的结合来抑制转化生长因子-β（TGF-β）信号传导。然而，TMEPAI 也被报道参与雄激素受体信号传导、磷酸酶和张力蛋白同源物缺失于 10 号染色体信号传导以及自噬体的形成，除了通过溶酶体降解 TGF-β 型 I 受体（TβRI）。因此，TMEPAI 似乎作为多个信号通路的调节剂。已经有很多人关注 TMEPAI 家族与致瘤性之间的关系。因此，在本文中，我们描述了对 TMEPAI 家族如何在生理上有助于细胞功能和疾病的理解的最新进展。
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