镰状细胞病血管阻塞性危象的研究。I. 己酮可可碱的作用。
Studies on vasoocclusive crisis of sickle cell disease. I. Effect of pentoxifylline.
作者信息
Ambrus J L, Ambrus C M, Gastpar H, Bannerman R, Bettigole R, Friedman S
出版信息
J Med. 1979;10(6):445-56.
PMID:299453
Abstract
A method was developed to induce and continuously monitor vasoocclusive crisis of sickle cell disease in non-human primates. Pentoxifylline, a phosphodiesterase inhibitory agent, showed significant preventive effect. This may be based on its ability to increase intracellular cAMP levels and consequently to decrease platelet aggregation and to increase red cell deformability.
摘要
已开发出一种在非人灵长类动物中诱导并持续监测镰状细胞病血管闭塞性危象的方法。磷酸二酯酶抑制剂己酮可可碱显示出显著的预防效果。这可能基于其提高细胞内cAMP水平的能力，从而降低血小板聚集并增加红细胞变形性。
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