外周血绝对单核细胞计数和淋巴细胞与单核细胞比值对间变大细胞淋巴瘤的预后意义。
Prognostic significance of peripheral blood absolute monocyte count and lymphocyte to monocyte ratio in anaplastic large cell lymphoma.
机构信息
Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, Jiangsu, China.
Key Laboratory of Hematology of Nanjing Medical University, Nanjing 210029, Jiangsu, China.
出版信息
Cancer Biomark. 2018;22(4):807-813. doi: 10.3233/CBM-181505.
BACKGROUND
Peripheral blood absolute monocyte count (AMC) and lymphocyte to monocyte ratio (LMR) have strong prognostic value in various forms of lymphomas. It was found that higher AMC and lower LMR were associated with poor prognosis in B cell lymphoma. However, their prognostic significance in systemic anaplastic large cell lymphoma (sALCL) remained to be determined.
OBJECTIVE
This study was aimed at investigating the prognostic significance of AMC and LMR in sALCL.
METHODS
A total of 29 newly diagnosed patients with sALCL were retrospectively included in study, prognostic significance of AMC, LMR, performance status (PS), international prognostic index (IPI), prognostic index for T-cell lymphomas (PIT) and other indicators were analyzed.
RESULTS
Univariate analysis showed high AMC, LMR < 2.5, PS ⩾ 2, extranodal involvement, no response to treatment and B symptoms predicted inferior PFS; LMR < 2.5, no response to treatment, elevated LDH, IPI ⩾ 3, PIT ⩾ 2 and PS ⩾ 2 predicted inferior OS. High AMC, PS ⩾ 2 were independent prognostic factors for PFS; PS ⩾ 2, no response to treatment and elevated LDH were independent prognostic factors for OS.
CONCLUSIONS
AMC was an independent prognostic factor for PFS in sALCL, and LMR < 2.5 also indicated poor prognosis.
背景
外周血绝对单核细胞计数（AMC）和淋巴细胞与单核细胞比值（LMR）在各种类型的淋巴瘤中具有很强的预后价值。研究发现，较高的 AMC 和较低的 LMR 与 B 细胞淋巴瘤的不良预后相关。然而，它们在系统性间变性大细胞淋巴瘤（sALCL）中的预后意义仍有待确定。
目的
本研究旨在探讨 AMC 和 LMR 在 sALCL 中的预后意义。
方法
回顾性纳入 29 例新诊断的 sALCL 患者，分析 AMC、LMR、体能状态（PS）、国际预后指数（IPI）、T 细胞淋巴瘤预后指数（PIT）等指标的预后意义。
结果
单因素分析显示，高 AMC、LMR<2.5、PS ⩾2、结外累及、无治疗反应和 B 症状预示着较差的 PFS；LMR<2.5、无治疗反应、LDH 升高、IPI ⩾3、PIT ⩾2 和 PS ⩾2 预示着较差的 OS。高 AMC、PS ⩾2 是 PFS 的独立预后因素；PS ⩾2、无治疗反应和 LDH 升高是 OS 的独立预后因素。
结论
AMC 是 sALCL 患者 PFS 的独立预后因素，LMR<2.5 也提示预后不良。
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