Li Na, Zhang Li, Song Hao-Lan, Zhang Jing, Weng Hua-Wei, Zou Li-Qun
1 Department of Medical Oncology of Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
2 Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Tumour Biol. 2017 May;39(5):1010428317705503. doi: 10.1177/1010428317705503.
Nasal-type, extranodal natural killer/T-cell lymphoma is a heterogeneous disorder with poor prognosis, requiring risk stratification in this population. The combined value of baseline absolute lymphocyte count and absolute monocyte count provided prognostic information in some malignancies. However, the evidence requires validation in extranodal natural killer/T-cell lymphoma. Aiming to investigate the prognostic significance of absolute lymphocyte count/absolute monocyte count ratio and absolute lymphocyte count/absolute monocyte count prognostic score for extranodal natural killer/T-cell lymphoma, a retrospective research was carried out. A total of 264 patients with newly diagnosed extranodal natural killer/T-cell lymphoma were analyzed in this study. The patients' absolute lymphocyte count and absolute monocyte count tested at initial diagnosis were collected. Receiver operating curve analysis showed that the optimal cut-off values for absolute lymphocyte count and absolute monocyte count were 1.0 × 10 and 0.5 × 10L, respectively, and for absolute lymphocyte count/absolute monocyte count ratio was 2.85. After a median follow-up of 27 months (range 1-87 months), the 3-year overall survival and progression-free survival was 75.4% and 67.6%, respectively. Patients with absolute lymphocyte count/absolute monocyte count ratio ≥ 2.85 had better 3-year overall survival and progression-free survival than those with absolute lymphocyte count/absolute monocyte count ratio <2.85 (p < 0.001). According to absolute lymphocyte count/absolute monocyte count prognostic score, significant difference has been noticed in 3-year overall survival and progression-free survival (p < 0.001) and high absolute lymphocyte count/absolute monocyte count prognostic score was associated with poorer survival. The International Prognostic Index and Korean Prognostic Index were used for prognosis and showed no significant difference. When adding absolute lymphocyte count/absolute monocyte count ratio and absolute lymphocyte count/absolute monocyte count prognostic score to the International Prognostic Index and Korean Prognostic Index model, additional prognostic information was found. These results suggest that absolute lymphocyte count/absolute monocyte count ratio and absolute lymphocyte count/absolute monocyte count prognostic score might be useful prognostic factors in extranodal natural killer/T-cell lymphoma.
鼻型结外自然杀伤/T细胞淋巴瘤是一种异质性疾病，预后较差，该人群需要进行风险分层。基线绝对淋巴细胞计数和绝对单核细胞计数的综合值在一些恶性肿瘤中提供了预后信息。然而，这一证据需要在结外自然杀伤/T细胞淋巴瘤中进行验证。为了研究绝对淋巴细胞计数/绝对单核细胞计数比值和绝对淋巴细胞计数/绝对单核细胞计数预后评分对结外自然杀伤/T细胞淋巴瘤的预后意义，开展了一项回顾性研究。本研究共分析了264例新诊断的结外自然杀伤/T细胞淋巴瘤患者。收集了患者初诊时检测的绝对淋巴细胞计数和绝对单核细胞计数。受试者工作特征曲线分析显示，绝对淋巴细胞计数和绝对单核细胞计数的最佳临界值分别为1.0×10和0.5×10/L，绝对淋巴细胞计数/绝对单核细胞计数比值的最佳临界值为2.85。中位随访27个月（范围1-87个月）后，3年总生存率和无进展生存率分别为75.4%和67.6%。绝对淋巴细胞计数/绝对单核细胞计数比值≥2.85的患者3年总生存率和无进展生存率优于绝对淋巴细胞计数/绝对单核细胞计数比值<2.85的患者（p<0.001）。根据绝对淋巴细胞计数/绝对单核细胞计数预后评分，3年总生存率和无进展生存率存在显著差异（p<0.001），绝对淋巴细胞计数/绝对单核细胞计数预后评分高与较差的生存率相关。国际预后指数和韩国预后指数用于预后评估，未显示出显著差异。当将绝对淋巴细胞计数/绝对单核细胞计数比值和绝对淋巴细胞计数/绝对单核细胞计数预后评分添加到国际预后指数和韩国预后指数模型中时，发现了额外的预后信息。这些结果表明，绝对淋巴细胞计数/绝对单核细胞计数比值和绝对淋巴细胞计数/绝对单核细胞计数预后评分可能是结外自然杀伤/T细胞淋巴瘤有用的预后因素。
