Chen Zhou, Huang He, Chen Qi-Yu
Department of Pharmacy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Zhongguo Zhong Yao Za Zhi. 2018 Jun;43(11):2391-2395. doi: 10.19540/j.cnki.cjcmm.20180305.001.
To investigate the curative effect of modified Buzhong Yiqi decoction combined with pelvic floor muscle exercise-biofeedback-electrostimulation on early postpartum pelvic floor dysfunction disease (PFD) and its effect on the expression of transforming growth factor (TGF-β1), matrix metalloprotein (MMP-2), and tissue inhibitor of metalloproteinase (TIMP-2). A total of 186 PFD patients admitted to our hospital from March 2014 to December 2016 were selected in the study and were randomly divided into test group (=93) and control group (=93). The control group received pelvic floor muscle exercises-biofeedback-electrostimulation, while the test group was additionally treated with modified Buzhong Yiqi decoction based on the treatment in control group. Then the clinical efficacy was compared between two groups. The results showed that vaginal contractile electromyography (EMG), duration of vaginal constriction, dynamic vaginal pressure and pelvic floor myoelectric activity in the test group at 1, 3 and 6 months after treatment were significantly higher than those before treatment and the control group (<0.05). The effective rate for urinary incontinence was 97.14% in test group, significantly higher than 75.68% in the control group (<0.05). The effective rate for improvement of sexual life quality was 96.43% in test group, significantly higher than 74.07% in control group (<0.05). 1, 3 and 6 months after treatment, the uterine prolapse, posterior wall prolapse and anterior wall prolapse grade in test group was slightly lower than that in the control group, but the difference was not statistically significant. After treatment, the levels of TGF-β1 and TIMP-2 in the test group were higher than those in the control group, while the levels of MMP-2 were lower than those in the control group (<0.05). The results showed that modified Buzhong Yiqi decoction combined with pelvic floor muscle exercise-biofeedback-electrostimulation can effectively relieve the clinical symptoms, promote the body recovery and improve the quality of sexual life in PFD patients, with remarkable advantages, so it is worthy of popularizing.
探讨加味补中益气汤联合盆底肌锻炼-生物反馈-电刺激对产后早期盆底功能障碍性疾病（PFD）的疗效及其对转化生长因子（TGF-β1）、基质金属蛋白酶（MMP-2）和金属蛋白酶组织抑制剂（TIMP-2）表达的影响。选取2014年3月至2016年12月我院收治的186例PFD患者进行研究，随机分为试验组（=93）和对照组（=93）。对照组接受盆底肌锻炼-生物反馈-电刺激，试验组在对照组治疗的基础上加用加味补中益气汤。然后比较两组的临床疗效。结果显示，试验组治疗后1、3、6个月的阴道收缩肌电图（EMG）、阴道缩窄持续时间、动态阴道压力和盆底肌电活动均显著高于治疗前及对照组（<0.05）。试验组尿失禁有效率为97.14%，显著高于对照组的75.68%（<0.05）。试验组性生活质量改善有效率为96.43%，显著高于对照组的74.07%（<0.05）。治疗后1、3、6个月，试验组子宫脱垂、后壁脱垂和前壁脱垂分级略低于对照组，但差异无统计学意义。治疗后，试验组TGF-β1和TIMP-2水平高于对照组，而MMP-2水平低于对照组（<0.05）。结果表明，加味补中益气汤联合盆底肌锻炼-生物反馈-电刺激可有效缓解PFD患者的临床症状，促进身体恢复，提高性生活质量，优势显著，值得推广。
