Yao Yuanshan, Zhou Yinjie, Yang Zhenhua, Shen Haibo
Department of Thoracic Surgery, Ningbo No.2 Hospital, Ningbo 315010, China.
Zhongguo Fei Ai Za Zhi. 2018 Jun 20;21(6):476-480. doi: 10.3779/j.issn.1009-3419.2018.06.09.
Lung cancer is the leading cause of cancer-related deaths, patients with non-small cell lung cancer (NSCLC) usually have distant metastases, such as bone metastasis, brain metastasis, and lung metastasis. The purpose of this study was to explore the risk factors for bone metastasis in NSCLC patients.
A total of 176 cases of NSCLC were selected from May 2009 to May 2011, and patients were divided into two groups, namely the bone metastasis group and non-bone metastasis group. The general clinicopathological data of the two groups and analyzing the independent risk factors of bone metastasis were compared.
In the general clinicopathological data of NSCLC patients. The thrombus or not and tumor-node-metastasis (TNM) stage were closely related to the occurrence of bone metastasis, and were statistically significant (all P<0.01). Prothrombin time, activated partial thromboplastin time, Fibrinogen, thrombin time, blood platelet, D-Dimer and alkaline phosphatase have significantly difference between the two groups (all P<0.05). Logistic regression analysis showed that fibrinogen, activated partial thromboplast in time, alkaline phosphatase, T4 phase, N3 phase and d-dimer were independent risk factors for bone metastasis in NSCLC patients.
CONCLUSIONS: Fibrinogen, alkaline phosphatase, T3, N2 stage and D-Dimer is the independent risk factors of bone metastases in patients with NSCLC. .
肺癌是癌症相关死亡的主要原因，非小细胞肺癌（NSCLC）患者通常会发生远处转移，如骨转移、脑转移和肺转移。本研究旨在探讨NSCLC患者骨转移的危险因素。
选取2009年5月至2011年5月期间的176例NSCLC患者，将患者分为两组，即骨转移组和非骨转移组。比较两组的一般临床病理资料并分析骨转移的独立危险因素。
在NSCLC患者的一般临床病理资料中。是否存在血栓以及肿瘤-淋巴结-转移（TNM）分期与骨转移的发生密切相关，且具有统计学意义（均P<0.01）。两组患者的凝血酶原时间、活化部分凝血活酶时间、纤维蛋白原、凝血酶时间、血小板、D-二聚体和碱性磷酸酶有显著差异（均P<0.05）。Logistic回归分析显示，纤维蛋白原、活化部分凝血活酶时间、碱性磷酸酶、T4期、N3期和D-二聚体是NSCLC患者骨转移的独立危险因素。
纤维蛋白原、碱性磷酸酶、T3、N2期和D-二聚体是NSCLC患者骨转移的独立危险因素。
