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粘连松解术治疗小肠梗阻后,修正后的心脏风险指数对心血管并发症的预测效果不佳。

Revised cardiac risk index poorly predicts cardiovascular complications after adhesiolysis for small bowel obstruction.

机构信息

Department of Surgery, Yale School of Medicine, New Haven, CT.

Department of Surgery, Yale School of Medicine, New Haven, CT.

出版信息

Surgery. 2018 Dec;164(6):1198-1203. doi: 10.1016/j.surg.2018.05.012. Epub 2018 Jun 24.

Abstract

BACKGROUND

The number of patients undergoing preoperative risk stratification in the United States is expected to increase as the population ages. A large percentage of patients undergo some form of preoperative testing, and society guidelines suggest that up to 50% of the testing in lower risk surgical subgroups is unnecessary. The Revised Cardiac Risk Index and the risk calculator of the American College of Surgeons National Surgical Quality Improvement Program are widely used tools as the first step of preoperative cardiac evaluation. The Revised Cardiac Risk Index was developed to fill a need for objective perioperative cardiac risk evaluation. Despite the ease of use of Revised Cardiac Risk Index, it is uncertain if the stratification is accurate for surgical patients because its accuracy in large surgical samples has not been tested. With the National Surgical Quality Improvement Program risk calculator having excellent accuracy in estimating cardiac complications (area under the receiver operating characteristic 0.895), a unique opportunity to test the predictive accuracy of postsurgical cardiac events became available. The purpose of this study is to determine the accuracy of the Revised Cardiac Risk Index for predicting cardiovascular complications after adhesiolysis for small bowel obstruction.

METHODS

From 2005 to 2015, 34,032 cases of open or laparoscopic adhesiolysis (Current Procedural Terminology codes 44005 and 44180) for small bowel obstruction (International Classification of Diseases, 10th edition [ICD-10]) were analyzed using the National Surgical Quality Improvement Program dataset. Revised Cardiac Risk Index estimates were calculated for each case and compared to reported cardiovascular complications (myocardial infarction or cardiac arrest) using univariable logistic regression. Overall predictive accuracy was assessed by measuring model discrimination (area under the receiver operating characteristic) and model calibration (Hosmer-Lemeshow chi-squared statistics).

RESULTS

Although the Revised Cardiac Risk Index predicted cardiovascular complications with an odds ratio of 2.3 and a 95% confidence interval of 1.9 to 2.8 (P < .001) and the Hosmer-Lemeshow chi-square was significant (0.22, P = 0.64), the area under the receiver operating characteristic was poor (0.63, 95% confidence interval 0.59-0.67).

CONCLUSION

Despite its relative simplicity, the Revised Cardiac Risk Index performed poorly as a predictor of cardiovascular complications after adhesiolysis for small bowel obstruction. These findings question the utility of the Revised Cardiac Risk Index in this patient population. Future studies should aim to develop models that are computationally simple while retaining predictive accuracy.

摘要

背景

随着人口老龄化,美国接受术前风险分层的患者数量预计将会增加。很大一部分患者接受某种形式的术前检查,社会指南建议,低风险手术亚组中多达 50%的检查是不必要的。修订后的心脏风险指数和美国外科医师学院国家手术质量改进计划的风险计算器是广泛使用的工具,作为术前心脏评估的第一步。修订后的心脏风险指数的开发是为了满足客观围手术期心脏风险评估的需求。尽管修订后的心脏风险指数易于使用,但尚不确定其对手术患者的分层是否准确,因为其在大型手术样本中的准确性尚未得到检验。由于国家手术质量改进计划风险计算器在估计心脏并发症方面具有出色的准确性(接受者操作特征曲线下面积为 0.895),因此有机会测试术后心脏事件的预测准确性。本研究的目的是确定修订后的心脏风险指数预测粘连松解术治疗小肠梗阻后心血管并发症的准确性。

方法

利用国家手术质量改进计划数据集,对 2005 年至 2015 年间 34032 例开放或腹腔镜粘连松解术(当前程序术语代码 44005 和 44180)治疗小肠梗阻(国际疾病分类,第 10 版 [ICD-10])的病例进行分析。为每个病例计算修订后的心脏风险指数估计值,并使用单变量逻辑回归将其与报告的心血管并发症(心肌梗死或心搏骤停)进行比较。通过测量模型判别力(接受者操作特征曲线下面积)和模型校准(Hosmer-Lemeshow χ 平方检验)来评估整体预测准确性。

结果

尽管修订后的心脏风险指数预测心血管并发症的比值比为 2.3,95%置信区间为 1.9 至 2.8(P<0.001),Hosmer-Lemeshow χ 平方检验显著(0.22,P=0.64),但接受者操作特征曲线下面积较差(0.63,95%置信区间 0.59-0.67)。

结论

尽管修订后的心脏风险指数相对简单,但作为小肠梗阻粘连松解术后心血管并发症的预测指标,其表现不佳。这些发现对该患者人群中修订后的心脏风险指数的实用性提出了质疑。未来的研究应旨在开发计算简单同时保留预测准确性的模型。

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