伴有胃泌素和血管活性肠肽分泌的胰岛细胞癌
Pancreatic islet cell carcinoma with gastrin and vasoactive intestinal polypeptide production.
作者信息
Barragry T P, Wick M R, Delaney J P
出版信息
Arch Surg. 1985 Oct;120(10):1178-81. doi: 10.1001/archsurg.1985.01390340074015.
The case history of a patient with an islet cell carcinoma, which produced both gastrin and vasoactive intestinal polypeptide (VIP), is presented. Although several examples have been observed of the combined production of these hormones by pancreatic endocrine tumors, few reports have related the clinical details of such cases. Resolution of diarrhea occurred in our patient after institution of nasogastric suction and cimetidine therapy, suggesting that gastric hypersecretion, rather than VIP activity, accounted for this problem. Chemotherapy with streptozotocin and 5-fluorouracil was highly effective in ameliorating clinical symptoms, diminishing serum levels of gastrin and VIP, and greatly reducing the bulk of metastatic disease in this case.
本文报告了一例胰岛细胞瘤患者的病例史，该肿瘤同时产生胃泌素和血管活性肠肽（VIP）。尽管已经观察到几例胰腺内分泌肿瘤联合产生这些激素的情况，但很少有报告涉及此类病例的临床细节。在我们的患者中，经鼻胃管抽吸和西咪替丁治疗后腹泻症状得到缓解，这表明是胃酸分泌过多而非VIP活性导致了这一问题。在该病例中，链脲佐菌素和5-氟尿嘧啶化疗在改善临床症状、降低胃泌素和VIP血清水平以及显著减少转移病灶体积方面非常有效。
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