Oberg K, Boström H, Fahrenkrug J, Dymling J F, Shaffalitsky de Muckadell O B, Lundqvist G
Acta Med Scand. 1979;206(3):223-7. doi: 10.1111/j.0954-6820.1979.tb13499.x.
A 57-year-old male patient with metastasizing non-beta islet cell carcinoma of the pancreas is described. Both gastrin and VIP levels were elevated and the patient suffered from a syndrome of pancreatic cholera and hyperacidity. The tumour contained gastrin and VIP as demonstrated by immunofluorescence. The patient also had a history of familial renal stone formation and parathyroid nodular hyperplasia. Resection of pancreatic tumour in 1973 resulted in four years without symptoms. In 1977 definite signs of multiple hepatic metastases appeared. These signs disappeared after streptozotocin given in a dosage of 2 g three times at weekly intervals. The patient had remained well for 20 months after this treatment. The causative agents for the clinical syndrome in this case are discussed in view of circulating hormone levels.
本文描述了一名57岁男性转移性胰腺非β胰岛细胞瘤患者。胃泌素和血管活性肠肽（VIP）水平均升高，患者患有胰性霍乱和胃酸过多综合征。免疫荧光显示肿瘤含有胃泌素和VIP。患者还有家族性肾结石形成和甲状旁腺结节性增生病史。1973年切除胰腺肿瘤后，患者四年无症状。1977年出现明确的多发性肝转移迹象。每周一次，每次2 g剂量的链脲佐菌素给药后，这些迹象消失。该治疗后患者保持良好状态20个月。根据循环激素水平讨论了该病例临床综合征的致病因素。
