Department of Cardiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Department of Interventional Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Hypertens Res. 2018 Sep;41(9):763-769. doi: 10.1038/s41440-018-0064-y. Epub 2018 Jun 26.
Preeclampsia affects 2-8% of all pregnancies, and it is associated with significant perinatal mortality and morbidities including preterm birth and small for gestational age. We examined whether plasma fatty acid binding protein 4 (FABP4) concentrations are associated with risk of later preeclampsia development. From March 2015 to May 2016, serum FABP4 was measured in 1486 women in early pregnancy. The relationship between the levels of FABP4 and preeclampsia were evaluated using univariate and multivariate regression analysis. The median plasma concentration of FABP4 at the first prenatal visit was significantly higher in women in whom preeclampsia developed later compared with those in whom it did not (P < 0.001). For each 1 unit increase in FABP4 plasma concentration, the unadjusted and adjusted risk of preeclampsia increased by 8% (odds ratio (OR): 1.08; 95% confidence interval [CI]: 1.05-1.12) and 4% (1.04; 95% CI: 1.02-1.07), respectively. The addition of FABP4 to established risk factors significantly improved net reclassification improvement. Increased FABP4 at the first prenatal visit of gestation independently predicted preeclampsia and significantly improved reclassification and discrimination. This information is important to guide public health efforts in preeclampsia prevention.
子痫前期影响所有妊娠的 2-8%，与围产期死亡率和发病率显著相关，包括早产和小于胎龄儿。我们研究了血浆脂肪酸结合蛋白 4（FABP4）浓度是否与子痫前期发展的风险相关。2015 年 3 月至 2016 年 5 月，对 1486 名早期妊娠妇女进行了血清 FABP4 测量。使用单变量和多变量回归分析评估了 FABP4 水平与子痫前期之间的关系。与未发生子痫前期的妇女相比，随后发生子痫前期的妇女在首次产前就诊时的血浆 FABP4 中位数明显更高（P<0.001）。FABP4 血浆浓度每增加 1 个单位，未经调整和调整的子痫前期风险分别增加 8%（比值比（OR）：1.08；95%置信区间[CI]：1.05-1.12）和 4%（1.04；95% CI：1.02-1.07）。将 FABP4 添加到已建立的危险因素中显著提高了净重新分类改善。妊娠首次产前就诊时 FABP4 升高独立预测子痫前期，并显著改善了重新分类和区分能力。这些信息对于指导子痫前期预防的公共卫生工作非常重要。
