Nuffield Department of Clinical Neurosciences and Department of Experimental Psychology, University of Oxford. John Radcliffe Hospital, Oxford, UK.
Institute of Cognitive Neuroscience, University College London, London, UK.
Nat Rev Neurosci. 2018 Aug;19(8):470-484. doi: 10.1038/s41583-018-0029-9.
Apathy and anhedonia are common syndromes of motivation that are associated with a wide range of brain disorders and have no established therapies. Research using animal models suggests that a useful framework for understanding motivated behaviour lies in effort-based decision making for reward. The neurobiological mechanisms underpinning such decisions have now begun to be determined in individuals with apathy or anhedonia, providing an important foundation for developing new treatments. The findings suggest that there might be some shared mechanisms between both syndromes. A transdiagnostic approach that cuts across traditional disease boundaries provides a potentially useful means for understanding these conditions.
冷漠症和快感缺失是常见的动机综合征，与广泛的大脑紊乱有关，且目前尚无确定的治疗方法。使用动物模型的研究表明，理解动机行为的一个有用框架是基于努力的奖励决策。支持这些决策的神经生物学机制现在已经在冷漠症或快感缺失患者中得到确定，为开发新的治疗方法提供了重要基础。研究结果表明，这两种综合征之间可能存在一些共同的机制。跨传统疾病边界的诊断方法为理解这些病症提供了一种潜在的有用手段。
