Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. China.
Chem Commun (Camb). 2018 Jul 10;54(56):7794-7797. doi: 10.1039/c8cc04027c.
The development of transition metal-catalyzed oxidative C-H/C-H cross-coupling between two (hetero)arenes to forge aryl-heteroaryl motifs under mild conditions is an appealing yet challenging task. Herein, we disclose a rhodium-catalyzed oxidative C-H/C-H cross-coupling reaction of an N-nitrosoaniline with a heteroarene under mild conditions. The judicious choice of the N-nitroso group as a directing group enables heightened reactivity. The coupled products could be transformed expediently to (2-aminophenyl)heteroaryl skeletons.
发展温和条件下过渡金属催化的两个（杂）芳环之间的氧化 C-H/C-H 交叉偶联反应，从而构建芳基-杂芳基结构是一项吸引人但具有挑战性的任务。在此，我们公开了在温和条件下使用 N-亚硝基苯胺与杂芳烃进行铑催化的氧化 C-H/C-H 交叉偶联反应。明智地选择 N-亚硝基作为导向基团可以提高反应活性。偶联产物可以方便地转化为（2-氨基苯基）杂芳基骨架。
