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The differential stimulation of brain and heart cyclic-AMP phosphodiesterase by oncomodulin.

作者信息

Mutus B, Karuppiah N, Sharma R K, MacManus J P

出版信息

Biochem Biophys Res Commun. 1985 Aug 30;131(1):500-6. doi: 10.1016/0006-291x(85)91830-3.

DOI:10.1016/0006-291x(85)91830-3
PMID:2994666
Abstract

Ca2+/calmodulin dependent cyclic nucleotide phosphodiesterase, from the bovine heart and brain, purified by monoclonal antibody chromatography were tested with respect to activation by oncomodulin. The heart and brain enzymes which have previously been shown to have slightly different electrophoretic mobilities (1), were found to also differ in the oncomodulin dose-dependent activation of cAMP hydrolysis. Oncomodulin was shown to activate the heart enzyme to the same extent as calmodulin. However, this study indicates that the heart phosphodiesterase has approximately 25-fold higher affinity for oncomodulin than the brain enzyme. The oncomodulin concentration required for the half-maximal activation of the heart phosphodiesterase was estimated to be 2 X 10(-7)M. In addition, the possibility of the observed activation by oncomodulin being due to calmodulin contamination can be ruled out as the oncomodulin activation profiles were unaltered subsequent to chromatography on organomercurial agarose and the activation by oncomodulin could not be reversed by anti-calmodulin IgG.

摘要

相似文献

1
The differential stimulation of brain and heart cyclic-AMP phosphodiesterase by oncomodulin.
Biochem Biophys Res Commun. 1985 Aug 30;131(1):500-6. doi: 10.1016/0006-291x(85)91830-3.
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Oncomodulin: The Enigmatic Parvalbumin Protein.癌调蛋白:神秘的小白蛋白
Front Mol Neurosci. 2019 Oct 9;12:235. doi: 10.3389/fnmol.2019.00235. eCollection 2019.
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Neurochem Res. 1998 Apr;23(4):533-8. doi: 10.1023/a:1022434602362.
3
Signal transduction: regulation of cAMP concentration in cardiac muscle by calmodulin-dependent cyclic nucleotide phosphodiesterase.
信号转导:钙调蛋白依赖性环核苷酸磷酸二酯酶对心肌中cAMP浓度的调节
Mol Cell Biochem. 1995 Aug-Sep;149-150:241-7. doi: 10.1007/BF01076583.
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Calcium-binding proteins: selective markers of nerve cells.钙结合蛋白:神经细胞的选择性标志物。
Cell Tissue Res. 1993 Feb;271(2):181-208. doi: 10.1007/BF00318606.
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Characterization of calmodulin-dependent cyclic nucleotide phosphodiesterase isoenzymes.钙调蛋白依赖性环核苷酸磷酸二酯酶同工酶的特性分析
Biochem J. 1994 Apr 1;299 ( Pt 1)(Pt 1):97-100. doi: 10.1042/bj2990097.
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Evolution of EF-hand calcium-modulated proteins. I. Relationships based on amino acid sequences.EF 手型钙调节蛋白的进化。I. 基于氨基酸序列的关系。
J Mol Evol. 1990 Jun;30(6):522-62. doi: 10.1007/BF02101108.