Sotak S, Felsoci M, Lazurova I
Bratisl Lek Listy. 2018;119(6):361-365. doi: 10.4149/BLL_2018_067.
To assess the prevalence of thyroid diseases in patients with type 2 diabetes mellitus (T2DM) in comparison with normal population; to determine prevalence of T2DM in patients with thyroid diseases.
First group consisted of 60 patients with T2DM without previous history of thyroid disease. Second group consisted of 60 patients with thyroid disease without any previously known impairment of glucose metabolism. Control group (CG) included 100 subjects who had no previous history of thyroid disease or glucose metabolism impairment. Blood tests were performed to evaluate thyroid and glucose metabolism parameters.
We found a significantly higher prevalence of thyroid diseases in patients with T2DM when compared to CG. Patients with T2DM showed to have higher serum levels of free triiodothyronine (fT3), thyroid‑stimulating hormone (TSH) and anti-thyroid peroxidase (anti-TPO) autoantibodies. We found no statistical significance in prevalence of T2DM in patients with thyroid diseases and CG. Among parameters of glucose metabolism, there were only higher fasting glucose levels in patients with hyperthyroidism and autoimmune thyroid disease (AITD).
Patients with T2DM showed to have higher prevalence of AITD and primary hypothyroidism. We did not find higher prevalence of T2DM in patients with thyroid diseases (Tab. 3, Ref. 29).
评估2型糖尿病（T2DM）患者甲状腺疾病的患病率，并与正常人群进行比较；确定甲状腺疾病患者中T2DM的患病率。
第一组由60例无甲状腺疾病既往史的T2DM患者组成。第二组由60例无任何已知既往糖代谢损害的甲状腺疾病患者组成。对照组（CG）包括100名无甲状腺疾病或糖代谢损害既往史的受试者。进行血液检测以评估甲状腺和糖代谢参数。
我们发现，与CG相比，T2DM患者中甲状腺疾病的患病率显著更高。T2DM患者的血清游离三碘甲状腺原氨酸（fT3）、促甲状腺激素（TSH）和抗甲状腺过氧化物酶（抗TPO）自身抗体水平更高。我们发现甲状腺疾病患者和CG中T2DM的患病率无统计学意义。在糖代谢参数中，仅甲状腺功能亢进症和自身免疫性甲状腺疾病（AITD）患者的空腹血糖水平较高。
T2DM患者的AITD和原发性甲状腺功能减退症患病率较高。我们未发现甲状腺疾病患者中T2DM的患病率更高（表3，参考文献29）。
