Huang Yun, Jiang Qing, Chen Yu-Hong, Zhang Da-Shan, Ding Wan-Jing, Ma Zhong-Jun
a Institute of Marine Biology , Ocean College, Zhejiang University , Zhoushan 316021 , China.
J Asian Nat Prod Res. 2019 Aug;21(8):826-831. doi: 10.1080/10286020.2018.1478814. Epub 2018 Jun 27.
A new medermycin analog () was isolated from the marine-derived actinomycetes sp. ZS-A45. The structure elucidation of compound was determined by the HRESIMS and extensive NMR analysis. And compound exhibited significant cytotoxicity against PC3 cell lines with IC values of 0.81 ± 0.42 m.
从海洋来源的放线菌ZS-A45中分离出一种新的美登霉素类似物（）。通过高分辨电喷雾电离质谱（HRESIMS）和广泛的核磁共振（NMR）分析确定了化合物的结构。并且化合物对PC3细胞系表现出显著的细胞毒性，半数抑制浓度（IC）值为0.81±0.42微摩尔。
