Hamari Chemicals Ltd, 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan.
Org Biomol Chem. 2018 Jul 11;16(27):4968-4972. doi: 10.1039/c8ob00963e.
We report a discovery of a new rimantadine [1-(1-adamantyl)ethanamine]-derived chiral ligand and its application for the preparation of α-amino acids using the second-order asymmetric transformation approach. The operational ease of experimental procedures coupled with excellent chemical yields and stereochemical outcome suggests some potential synthetic generality of this approach.
我们报告了一种新的金刚烷[1-(1-金刚烷基)乙胺]-衍生的手性配体的发现及其在使用二阶不对称转化方法制备α-氨基酸中的应用。实验程序的操作简便性与出色的化学收率和立体化学结果相结合，表明这种方法具有一定的潜在合成通用性。
