Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Institute of Pharmacy, Yerevan State University, 1 Alex Manoogian Str., Yerevan 0025, Armenia.
Molecules. 2020 Jun 12;25(12):2739. doi: 10.3390/molecules25122739.
Tailor-made amino acids are indispensable structural components of modern medicinal chemistry and drug design. Consequently, stereo-controlled preparation of amino acids is the area of high research activity. Over last decade, application of Ni(II) complexes of Schiff bases derived from glycine and chiral tridentate ligands has emerged as a leading methodology for the synthesis of various structural types of amino acids. This review article summarizes examples of asymmetric synthesis of tailor-made α-amino acids via the corresponding Ni(II) complexes, reported in the literature over the last four years. A general overview of this methodology is provided, with the emphasis given to practicality, scalability, cost-structure and recyclability of the chiral tridentate ligands.
定制氨基酸是现代医学化学和药物设计不可或缺的结构组成部分。因此，立体控制氨基酸的制备是一个高度活跃的研究领域。在过去的十年中，源自甘氨酸和手性三齿配体的席夫碱的 Ni(II)配合物的应用已经成为合成各种结构类型氨基酸的主要方法。本文综述了过去四年文献中报道的通过相应的 Ni(II)配合物不对称合成定制的α-氨基酸的实例。提供了对该方法的概述，重点是手性三齿配体的实用性、可扩展性、成本结构和可回收性。
