有早期生活虐待史的女性的母脑：基于想象的 fMRI 研究冲突与愉快的与孩子的互动。
The maternal brain in women with a history of early-life maltreatment: an imagination-based fMRI study of conflictual versus pleasant interactions with children.
机构信息
From the Department of General Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Germany (Neukel, Zietlow, Reck, Herpertz); the Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Germany (Fuchs, Brunner); the Department of Psychology, Faculty of Psychology and Educational Science, Ludwig-Maximilian University of Munich, Germany (Reck); the Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatic Medicine, SHG Hospital, Kleinblittersdorf, Germany (Moehler); and the Department of Psychiatry and Psychotherapy, University Medicine Berlin, Charité Campus Mitte, Berlin, Germany (Bermpohl).
出版信息
J Psychiatry Neurosci. 2018 Jul;43(4):273-282. doi: 10.1503/jpn.170026.
BACKGROUND
Early-life maltreatment has severe consequences for the affected individual, and it has an impact on the next generation. To improve understanding of the intergenerational effects of abuse, we investigated the consequences of early-life maltreatment on maternal sensitivity and associated brain mechanisms during mother-child interactions.
METHODS
In total, 47 mothers (22 with a history of physical and/or sexual childhood abuse and 25 without, all without current mental disorders) took part in a standardized real-life interaction with their 7- to 11-year-old child (not abused) and a subsequent functional imaging script-driven imagery task.
RESULTS
Mothers with early-life maltreatment were less sensitive in real-life mother-child interactions, but while imagining conflictual interactions with their child, they showed increased activation in regions of the salience and emotion-processing network, such as the amygdala, insula and hippocampus. This activation pattern was in contrast to that of mothers without early-life maltreatment, who showed higher activations in those regions in response to pleasant mother-child interactions. Mothers with early-life maltreatment also showed reduced functional connectivity between regions of the salience and the mentalizing networks.
LIMITATIONS
Region-of-interest analyses, which were performed in addition to whole-brain analyses, were exploratory in nature, because they were not further controlled for multiple comparisons.
CONCLUSION
Results suggest that for mothers with early-life maltreatment, conflictual interactions with their child may be more salient and behaviourally relevant than pleasant interactions, and that their salience network is poorly modulated by the brain regions involved in mentalizing processes. This activation pattern offers new insights into the mechanisms behind the intergenerational effects of maltreatment and into options for reducing these effects.
背景
儿童期虐待对受影响个体有严重后果，并且对下一代也有影响。为了增进对虐待的代际影响的理解，我们研究了儿童期虐待对母婴互动期间母亲敏感性的影响及其相关的大脑机制。
方法
共有 47 名母亲（22 名有身体和/或性虐待史，25 名无，均无当前精神障碍）参与了与 7 至 11 岁儿童（未受虐待）的标准化现实互动以及随后的功能成像脚本驱动想象任务。
结果
有儿童期虐待史的母亲在现实生活中的母婴互动中不太敏感，但当想象与孩子发生冲突性互动时，她们的大脑中与突显和情绪处理网络相关的区域（如杏仁核、脑岛和海马体）的活跃度增加。这种激活模式与没有儿童期虐待史的母亲不同，后者在对愉快的母婴互动的反应中显示出这些区域的更高激活。有儿童期虐待史的母亲的突显和心理化网络之间的功能连接也减少了。
局限性
除了全脑分析外，还进行了感兴趣区域分析，这些分析是探索性的，因为它们没有进一步针对多重比较进行控制。
结论
结果表明，对于有儿童期虐待史的母亲来说，与孩子的冲突性互动可能比愉快的互动更显著和具有行为相关性，并且他们的突显网络对参与心理化过程的大脑区域的调节较差。这种激活模式为虐待的代际影响背后的机制以及减少这些影响的方法提供了新的见解。
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