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Interaction of vasoactive intestinal peptide with rat small intestinal epithelial cells after intestinal resection.

作者信息

Diaz-Juarez J L, Bodega G, Arilla E, Prieto J C

出版信息

Biosci Rep. 1985 Jul;5(7):559-66. doi: 10.1007/BF01117068.

DOI:10.1007/BF01117068
PMID:2994772
Abstract

Specific binding of vasoactive intestinal peptide (VIP) and VIP-stimulated cyclic AMP accumulation were studied in small intestinal epithelial cells (both of crypt and villous levels) 3, 7 and 14 d after a 60% resection of the small intestine. The affinity, but not the binding capacity, of VIP receptors decreased during the adaptive hyperplastic response. Basal cyclic AMP levels were similar in cells of both control and resected rats. Resection induced a decrease of potency, but not of efficiency, of VIP on the stimulation of cyclic AMP accumulation.

摘要

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