肠上皮细胞中的肠血管活性肽受体：特异性结合与环磷酸腺苷的刺激
[Intestinal vasoactive peptide receptors in enterocytes : specific binding and stimulation of cyclic AMP].
作者信息
Laburthe M, Besson J, Bon Hoa D H, Rosselin G
出版信息
C R Acad Hebd Seances Acad Sci D. 1977 Jun 6;284(21):2139-42.
PMID:195749
Abstract
Receptors for the vasoactive intestinal peptide (VIP) were characterized on enterocytes isolated from Rat small intestine. Native VIP inhibited competitively the binding of 125I-VIP to enterocytes and strongly stimulated cyclic AMP production; both these effects were observed for concentrations of VIP as low as 0.5-1.0 ng/ml (0.15-0.30 nM) which are compatible with the VIP concentration in the gut.
摘要
对从大鼠小肠分离出的肠上皮细胞上的血管活性肠肽（VIP）受体进行了特性鉴定。天然VIP竞争性抑制125I-VIP与肠上皮细胞的结合，并强烈刺激环磷酸腺苷（cAMP）的产生；在低至0.5 - 1.0 ng/ml（0.15 - 0.30 nM）的VIP浓度下就观察到了这两种效应，该浓度与肠道中的VIP浓度相符。
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