Hans Christian Andersen Children's Hospital, Odense University Hospital, Kløvervænget 23C, 5000, Odense C, Denmark.
Department of Clinical Research, University of Southern Denmark, Winsløwparken 19, 3, 5000, Odense C, Denmark.
Osteoporos Int. 2018 Aug;29(8):1843-1852. doi: 10.1007/s00198-018-4556-z. Epub 2018 Jun 12.
Bone mass in childhood is highly influenced by puberty. At the same age, bone mass was higher for pubertal than pre-pubertal children. A high level of tracking during 7 years from childhood through puberty was shown, indicating that early levels of bone mass may be important for later bone health.
Bone mass development in childhood varies by sex and age, but also by pubertal stage. The objectives of this study were to (1) describe bone mass development in childhood as it relates to pubertal onset and to (2) determine the degree of tracking from childhood to adolescence.
A longitudinal study with 7 years of follow-up was initiated in 2008 to include 831 children (407 boys) aged 8 to 17 years. Participants underwent whole body dual-energy X-ray absorptiometry (DXA) scanning, blood collection to quantify luteinizing hormone levels, and Tanner stage self-assessment three times during the 7-year follow-up. Total body less head bone mineral content, areal bone mineral density, and bone area were used to describe development in bone accrual and to examine tracking over 7 years.
Bone mass in pubertal children is higher than that of pre-pubertal children at the same age. Analysing tracking with quintiles of bone mass Z-scores in 2008 and 2015 showed that more than 80% of participants remained in the same or neighbouring quintile over the study period. Tracking was confirmed by correlation coefficients between Z-scores at baseline and 7-year follow-up (range, 0.80-0.84).
Bone mass is highly influenced by pubertal onset, and pubertal stage should be considered when examining children's bone health. Because bone mass indices track from childhood into puberty, children with low bone mass may be at risk of developing osteoporosis later in life.
描述儿童期骨量发育与青春期开始的关系，并确定从儿童期到青春期的跟踪程度。
2008 年启动了一项纵向研究，对 8 至 17 岁的 831 名儿童（407 名男孩）进行了为期 7 年的随访。参与者接受了全身双能 X 线吸收法（DXA）扫描、采血以定量测定黄体生成激素水平以及在 7 年随访期间进行 3 次自我评估的 Tanner 分期。使用全身（不包括头部）骨矿物质含量、面积骨矿物质密度和骨面积来描述骨量积累的发育情况，并检查 7 年内的跟踪情况。
在相同年龄，青春期儿童的骨量高于青春期前儿童。通过分析 2008 年和 2015 年骨量 Z 分数的五分位数的跟踪情况，发现研究期间超过 80%的参与者仍处于同一或相邻五分位数。通过基线和 7 年随访的 Z 分数之间的相关系数（范围为 0.80-0.84）证实了跟踪情况。
骨量受青春期开始的影响很大，在检查儿童的骨骼健康时应考虑青春期阶段。由于骨量指数从儿童期到青春期持续跟踪，因此骨量低的儿童可能有患骨质疏松症的风险。
