Clinical Radiology, Imaging Sciences and Biomedical Engineering, The University of Manchester, Manchester, UK.
Osteoporos Int. 2011 Jan;22(1):121-32. doi: 10.1007/s00198-010-1216-3. Epub 2010 Mar 24.
Changes and gender differences in the muscle bone unit at different skeletal sites were investigated during pubertal development. Females accrued greater BMC in relation to muscle compared to males; these gender differences were greater after adjustment for height and regional fat mass.
To describe changes and gender differences in the muscle-bone unit at different skeletal sites during pubertal development.
Four hundred forty-two children aged 5-18 years were studied. Measurements of bone mineral content (BMC), lean mass (LM) and fat mass of the whole body (WB), legs, arms and lumbar spine were obtained from dual-energy X-ray absorptiometry. Peripheral quantitative computed tomography was used to measure BMC of the radius diaphysis and cross-sectional muscle area (CSMA) of the mid-forearm. These measurements were used to describe differences between, and within, genders at each pubertal stage in BMC accrual relative to muscle, both before and after adjustment for height, regional fat and muscle at central and peripheral skeletal sites.
In males, there were significant increases in adjusted WB and leg BMC at the end of pubertal development. Unadjusted and adjusted lumbar spine BMC increased at the onset of, and at the end, of puberty. Radius BMC increased at most pubertal stages. In females, there were increases in unadjusted and adjusted whole body BMC at late puberty, in leg BMC at the onset of puberty and at pubertal stage four. Unadjusted arm BMC increased at most pubertal stages; however, after adjustment, an increase occurred at pubertal stage four. Both adjusted and unadjusted lumbar spine BMC increased at pubertal stage four. Unadjusted radius BMC increased at most pubertal stages. Females had greater BMC at all skeletal sites, compared to males, except at the radius, where adjusted BMC was greater in males at pubertal stage four.
Males and females accrue more BMC in relation to lean mass at multiple skeletal sites as puberty proceeds. Females accrue more BMC in relation to lean mass, in comparison to males, at most skeletal sites.
描述青春期发育过程中不同骨骼部位肌肉-骨骼单位的变化和性别差异。
对 442 名 5-18 岁儿童进行研究。使用双能 X 射线吸收法测量全身（WB）、腿部、手臂和腰椎的骨矿物质含量（BMC）、瘦体重（LM）和脂肪量。使用外周定量计算机断层扫描测量桡骨干的 BMC 和前臂中部的 CSA。这些测量值用于描述在每个青春期阶段，男女之间以及男女内部，BMC 相对于肌肉的增长差异，包括身高、中央和外周骨骼部位的区域脂肪和肌肉调整前后。
在男性中，青春期结束时 WB 和腿部 BMC 的调整后值有显著增加。未调整和调整后的腰椎 BMC 在青春期开始和结束时增加。桡骨 BMC 在大多数青春期阶段都增加。在女性中，整个身体的未调整和调整后的 BMC 在青春期晚期增加，腿部 BMC 在青春期开始时增加，在青春期第四阶段增加。手臂的未调整 BMC 在大多数青春期阶段增加；然而，调整后，在青春期第四阶段增加。调整后的和未调整的腰椎 BMC 在青春期第四阶段增加。未调整的桡骨 BMC 在大多数青春期阶段增加。与男性相比，女性在所有骨骼部位的 BMC 都较高，除了桡骨，在青春期第四阶段男性的 BMC 较高。
随着青春期的进展，男性和女性在多个骨骼部位的 BMC 相对于瘦体重的增长。与男性相比，女性在大多数骨骼部位的 BMC 相对于瘦体重的增长更多。
