儿童吉兰-巴雷综合征：亚型与预后
Guillain-Barré syndrome in children: subtypes and outcome.
作者信息
Karalok Zeynep Selen, Taskin Birce Dilge, Yanginlar Zeliha Brohi, Gurkas Esra, Guven Alev, Degerliyurt Aydan, Unlu Ece, Kose Gulsen
机构信息
Department of Pediatric Neurology, Ankara Children's Hematology-Oncology Training and Research Hospital, 06110, Dıskapı/Ankara, Turkey.
Department of Physical Medicine and Rehabilitation, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
出版信息
Childs Nerv Syst. 2018 Nov;34(11):2291-2297. doi: 10.1007/s00381-018-3856-0. Epub 2018 Jun 14.
OBJECTIVE
This study reviews the clinical features, subtypes, and outcomes of childhood Guillain-Barré syndrome (GBS).
METHODS
Fifty-four children who attended a tertiary care training and research hospital in Turkey were enrolled in the study.
RESULTS
The mean age was 6.5 ± 4.2 years and 32 patients (59.5%) were male. The most common subtype of GBS was acute inflammatory demyelinating polyneuropathy (AIDP), which was seen in 27 patients (50%). Having antecedent history, especially upper respiratory tract infection was significantly more common in AIDP (P = 0.028). Sensorial symptoms were significantly more frequent in axonal type GBS (P = 0.001). When we compare the demyelinating and axonal forms, all of the groups had favorable outcome.
CONCLUSION
The diagnosis of pediatric GBS can be delayed because of its variable presentation. Early admission to hospital and early treatment are important for decreasing the need for respiratory support and improving the outcome.
目的
本研究回顾儿童吉兰-巴雷综合征（GBS）的临床特征、亚型及预后。
方法
54名在土耳其一家三级护理培训与研究医院就诊的儿童纳入本研究。
结果
平均年龄为6.5±4.2岁，32例患者（59.5%）为男性。GBS最常见的亚型是急性炎症性脱髓鞘性多发性神经病（AIDP），见于27例患者（50%）。有前驱病史，尤其是上呼吸道感染在AIDP中显著更常见（P = 0.028）。感觉症状在轴索性GBS中显著更频繁（P = 0.001）。当我们比较脱髓鞘型和轴索型时，所有组预后良好。
结论
由于小儿GBS表现多样，其诊断可能会延迟。早期入院和早期治疗对于减少呼吸支持需求及改善预后很重要。
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