与格林-巴利综合征患儿需要机械通气相关的危险因素。
Risk factors associated with the need for mechanical ventilation in children with Guillain-Barré syndrome.
机构信息
Department of Electrophysiology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430016, China (Jiang J, Email:jiangjuntg@sina. com).
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2021;23(9):922-926. doi: 10.7499/j.issn.1008-8830.2106003.
OBJECTIVES
To study the risk factors associated with the need for mechanical ventilation in children with Guillain-Barré syndrome (GBS).
METHODS
The medical data of 107 children with GBS were retrospectively reviewed. According to whether mechanical ventilation was required, the children were divided into a mechanical ventilation group with 16 children and a non-mechanical ventilation group with 91 children. The risk factors associated with the need for mechanical ventilation in children with GBS were identified by a multivariate logistic regression analysis.
RESULTS
Among the 107 children, 16 (15.0%) required mechanical ventilation. Compared with the non-mechanical ventilation group, the mechanical ventilation group had a significantly higher proportion of children with facial and/or bulbar muscle weakness, a significantly shorter duration from the onset to the peak of the disease, and a significantly higher Hughes Functional Grading Scale score at the first visit (<0.05). Facial and/or bulbar muscle weakness and short duration from the onset to the peak of the disease were risk factors associated with the need for mechanical ventilation in children with GBS (=5.053 and 1.239 respectively, <0.05).
CONCLUSIONS
Facial and/or bulbar muscle weakness and short duration from the onset to the peak of the disease may increase the risk of mechanical ventilation in children with GBS. .
目的
研究与吉兰-巴雷综合征（GBS）患儿需要机械通气相关的危险因素。
方法
回顾性分析 107 例 GBS 患儿的临床资料。根据是否需要机械通气，将患儿分为机械通气组 16 例和非机械通气组 91 例。采用多因素 logistic 回归分析确定与 GBS 患儿机械通气需求相关的危险因素。
结果
在 107 例患儿中，有 16 例（15.0%）需要机械通气。与非机械通气组相比，机械通气组患儿存在面部和/或球部肌肉无力的比例显著更高，疾病从发病到高峰的时间显著更短，首次就诊时 Hughes 功能分级量表评分显著更高（<0.05）。面部和/或球部肌肉无力以及疾病从发病到高峰的时间较短是 GBS 患儿需要机械通气的危险因素（=5.053 和 1.239，<0.05）。
结论
面部和/或球部肌肉无力以及疾病从发病到高峰的时间较短可能会增加 GBS 患儿机械通气的风险。
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