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[类固醇植入物治疗交感性眼炎:在交感性眼炎背景下玻璃体内植入地塞米松治疗黄斑囊样水肿]

[Steroid implant in treatment of sympathetic ophthalmia : Intravitreal implant of dexamethasone in cystoid macular edema in the context of sympathetic ophthalmia].

作者信息

Wocker L, Januschowski K

机构信息

Knappschaft Augenklinik Sulzbach, An der Klinik 10, 66280, Sulzbach/Saar, Deutschland.

Universitätsaugenklinik Tübingen, Eberhard-Karls-Universität Tübingen, Tübingen, Deutschland.

出版信息

Ophthalmologe. 2019 Apr;116(4):380-383. doi: 10.1007/s00347-018-0748-3.

DOI:10.1007/s00347-018-0748-3
PMID:29948149
Abstract

We present the case of a 39-year-old female patient with cystoid macular edema of the left eye in the context of sympathetic ophthalmia. The right eye underwent several surgical interventions of both cornea and retina after ocular trauma and was enucleated after first clinical signs compatible with sympathetic ophthalmia and after exclusion of other infectious/non-infectious etiologies. The patient was treated with parabulbar triamcinolone injections and intravitreal injections of a dexamethasone slow-release implant with a good clinical course with respect to the macular edema. A steroid response did not occur over the treatment period of more than 12 months.

摘要

我们报告了一例39岁女性患者,其左眼在交感性眼炎的背景下出现了黄斑囊样水肿。右眼在眼外伤后接受了角膜和视网膜的多次手术干预,在出现与交感性眼炎相符的最初临床症状并排除其他感染性/非感染性病因后被摘除。该患者接受了球周曲安奈德注射和玻璃体内注射地塞米松缓释植入物治疗,黄斑水肿的临床病程良好。在超过12个月的治疗期内未出现类固醇反应。

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引用本文的文献

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Sympathetic Ophthalmia: Where Do We Currently Stand on Treatment Strategies?交感性眼炎:我们目前在治疗策略方面处于什么状况?
Clin Ophthalmol. 2021 Oct 20;15:4201-4218. doi: 10.2147/OPTH.S289688. eCollection 2021.

本文引用的文献

1
Intravitreal Dexamethasone Implant for the Treatment of Macular Edema in Chronic Non-infectious Uveitis.玻璃体内注射地塞米松植入物治疗慢性非传染性葡萄膜炎相关黄斑水肿。
Ocul Immunol Inflamm. 2017 Oct;25(5):685-692. doi: 10.3109/09273948.2016.1160130. Epub 2016 May 18.
2
Management of sympathetic ophthalmia with the fluocinolone acetonide implant.曲安奈德植入物治疗交感性眼炎
Ophthalmology. 2009 Mar;116(3):552-557.e1. doi: 10.1016/j.ophtha.2008.10.024. Epub 2009 Jan 14.
3
Sympathetic ophthalmia.交感性眼炎
Semin Ophthalmol. 2005 Jul-Sep;20(3):191-7. doi: 10.1080/08820530500232100.
4
Intravitreal triamcinolone acetonide for treatment of sympathetic ophthalmia.玻璃体内注射曲安奈德治疗交感性眼炎。
Am J Ophthalmol. 2004 Feb;137(2):367-8. doi: 10.1016/S0002-9394(03)00899-7.
5
Immunohistochemistry and electron microscopy of choroidal infiltrates and Dalen-Fuchs nodules in sympathetic ophthalmia.交感性眼炎脉络膜浸润及Dalen-Fuchs结节的免疫组织化学和电子显微镜检查
Ophthalmology. 1985 Apr;92(4):580-90. doi: 10.1016/s0161-6420(85)34006-x.
6
Sympathetic ophthalmia. A long-term follow-up.交感性眼炎。一项长期随访研究。
Arch Ophthalmol. 1978 Feb;96(2):257-62. doi: 10.1001/archopht.1978.03910050125004.
7
Recent advances in sympathetic ophthalmia.交感性眼炎的最新进展
Surv Ophthalmol. 1979 Nov-Dec;24(3):141-56. doi: 10.1016/0039-6257(79)90018-3.