Centre de Neurosciences Psychiatriques, Hôpital de Cery/CHUV, Route de Cery, 1008, Prilly, Switzerland.
Cell Tissue Res. 2019 Jan;375(1):93-101. doi: 10.1007/s00441-018-2862-6. Epub 2018 Jun 8.
The central amygdala has a rich repertoire of neuropeptides and neuropeptide receptors. The diverse ways in which they modulate neuronal activity and influence synaptic activity are discussed here mostly in the context of fear and anxiety-related behaviour but also with respect to nociception, hunger and satiety and chronic alcohol exposure that often come together with anxiety. It appears that neuropeptides exert rather specific effects on behaviour and physiology that can be quite different from the effects evoked by opto- or chemogenetical stimulation of the central amygdala neurons that synthesise them or express their receptors. Also, neuropeptides might work synergistically or antagonistically to fine-tune the final outcome of sensory processing in the central amygdala and bring about appropriate physiological and behavioural responses to threat. Taken together, we propose that neuropeptide signalling in the central amygdala mainly serves to establish or maintain emotional homeostasis in response to threatening and other sensory stimuli.
杏仁中央核含有丰富的神经肽和神经肽受体。本文主要讨论了它们调节神经元活动和影响突触活动的多种方式，这些方式大多与恐惧和焦虑相关的行为有关，但也与痛觉、饥饿和饱腹感以及慢性酒精暴露有关，这些通常与焦虑同时发生。似乎神经肽对行为和生理有相当特定的影响，这些影响可能与光遗传学或化学遗传学刺激合成或表达其受体的杏仁中央核神经元所引起的影响有很大不同。此外，神经肽可能协同或拮抗作用，以微调杏仁中央核中感觉处理的最终结果，并对威胁产生适当的生理和行为反应。总的来说，我们提出杏仁中央核中的神经肽信号主要用于建立或维持对威胁和其他感觉刺激的情绪平衡。
