Soares Raquel Gusmão, Farias Lucyana Conceição, da Silva Menezes Agna Soares, de Oliveira E Silva Carla Silvana, Tabosa Angeliny Tamiarana Lima, Chagas Pablo Vinicyus Ferreira, Santiago Laís, Santos Sérgio Henrique Sousa, de Paula Alfredo Maurício Batista, Guimarães André Luiz Sena
Department of Dentistry, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil.
Department of Nursy, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil.
Lasers Med Sci. 2018 Nov;33(8):1813-1819. doi: 10.1007/s10103-018-2549-y. Epub 2018 Jun 15.
Oral squamous cell carcinoma (OSCC) is the most frequent oral malignant neoplasia. As consequence of OSCC treatment, oral mucositis (OM) is one of the most common adverse effects of OSCC treatment. Currently, there is no consensus for OM treatment. The purpose of the current study was to test the combination of red and infrared low-level laser therapy (LLLT) for OM treatment. Primary culture of human fibroblast was performed to identify LLLT dose. After laboratory tests, a two-arm parallel, single-blind, controlled study was conducted. The two arms were group 1, both 660- and 808-nm wavelengths (300 J/cm, 9 J of total energy, 100 mW, spot size 3 mm), and group 2, only 660-nm wavelength (300 J/cm, 9 J of total energy, 100 mW, spot size 3 mm). Both treatments were performed twice a week. Group 1 presented a reduction of mucositis grade in comparison to group 2. Group 1 also presented reduction of analgesics prescription. But no significant differences between groups 1 and 2 were observed according to the pain scale. In conclusion, the current study demonstrated that a combination of red and infrared at a higher dose (300 J/cm) reduced both oral mucositis grade and analgesics prescription. The effects of the combination of RT and LLLT are unclear and need more studies.
口腔鳞状细胞癌（OSCC）是最常见的口腔恶性肿瘤。作为OSCC治疗的结果，口腔黏膜炎（OM）是OSCC治疗最常见的不良反应之一。目前，对于OM的治疗尚无共识。本研究的目的是测试红激光和红外低强度激光疗法（LLLT）联合治疗OM的效果。进行人成纤维细胞原代培养以确定LLLT剂量。经过实验室检测后，开展了一项双臂平行、单盲对照研究。两组分别为：第1组，660纳米和808纳米波长（300 J/cm，总能量9 J，100 mW，光斑尺寸3毫米）；第2组，仅660纳米波长（300 J/cm，总能量9 J，100 mW，光斑尺寸3毫米）。两种治疗均每周进行两次。与第2组相比，第1组的黏膜炎分级有所降低。第1组的镇痛药处方量也有所减少。但根据疼痛量表，第1组和第2组之间未观察到显著差异。总之，本研究表明，高剂量（300 J/cm）的红激光和红外激光联合应用可降低口腔黏膜炎分级和镇痛药处方量。放疗和LLLT联合应用的效果尚不清楚，需要更多研究。
