Cauwels R G E C, Martens L C
Dept of Paediatric Dentistry, University Hospital, De Pintelaan 158, B 9000 Ghent, Belgium.
Eur Arch Paediatr Dent. 2011 Apr;12(2):118-23. doi: 10.1007/BF03262791.
The goal of this pilot study was to investigate the capacity of pain relief and wound healing of low level laser therapy (LLLT) in chemotherapy-induced oral mucositis (OM) in a paediatric oncology population group.
16 children (mean age 9.4 years) from the Gent University Hospital - Department Paediatric Oncology/haematology, suffering from chemotherapy-induced OM were selected. During clinical investigations, the OM grade was assessed using the WHO classification. All children were treated using a GaAlAs diode laser with 830 nm wavelength and a potency of 150 mW. The energy released was adapted according to the severity of the OM lesions. The same protocol was repeated every 48 hrs until healing of each lesion occurred. Subjective pain was monitored before and immediately after treatment by an appropriate pain scale and functional impairment was recorded. At each visit, related blood cell counts were recorded.
After 12 mths, records were evaluated and information about treatment sequence, treatment sessions and frequencies related to the pain sensation and comfort were registered. Immediately after beaming the OM, pain relief was noticed. Depending on the severity of OM, on average, 2.5 treatments per lesion in a period of 1 week were sufficient to heal a mucositis lesion.
LLLT, one of the most recent and promising treatment therapies, has been shown to reduce the severity and duration of mucositis and to relieve pain significantly. In the present study similar effects were obtained with the GaAlAs 830nm diode laser. It became clear that using the latter diode device, new guidelines could be developed as a function of the WHO-OM grades i.e. the lower the grade, the less energy needed. Immediate pain relief and improved wound healing resolved functional impairment that was obtained in all cases.
本初步研究的目的是调查低强度激光疗法（LLLT）对儿科肿瘤患者化疗引起的口腔黏膜炎（OM）的止痛和伤口愈合能力。
从根特大学医院儿科肿瘤/血液科选取16名患有化疗引起的OM的儿童（平均年龄9.4岁）。在临床研究期间，使用世界卫生组织分类评估OM等级。所有儿童均使用波长830nm、功率150mW的GaAlAs二极管激光器进行治疗。释放的能量根据OM病变的严重程度进行调整。每48小时重复相同方案，直至每个病变愈合。在治疗前和治疗后立即通过适当的疼痛量表监测主观疼痛，并记录功能障碍。每次就诊时记录相关血细胞计数。
12个月后，评估记录并登记有关治疗顺序、治疗次数和与疼痛感觉及舒适度相关的频率的信息。照射OM后立即注意到疼痛缓解。根据OM的严重程度，平均在1周内每个病变进行2.5次治疗足以治愈黏膜炎病变。
LLLT是最新且最有前景的治疗方法之一，已被证明可降低黏膜炎的严重程度和持续时间，并显著缓解疼痛。在本研究中，使用GaAlAs 830nm二极管激光器获得了类似效果。很明显，使用后一种二极管设备，可以根据世界卫生组织OM等级制定新的指导方针，即等级越低所需能量越少。立即缓解疼痛和改善伤口愈合解决了所有病例中出现的功能障碍。
