基于 [F]FDG PET/CT 影像组学的代谢成像表型与结直肠癌的遗传改变相关。
Metabolic Imaging Phenotype Using Radiomics of [F]FDG PET/CT Associated with Genetic Alterations of Colorectal Cancer.
机构信息
Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan.
Graduate Institute of Clinical Medical Science, School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung, 404, Taiwan.
出版信息
Mol Imaging Biol. 2019 Feb;21(1):183-190. doi: 10.1007/s11307-018-1225-8.
PURPOSE
To understand the association between genetic mutations and radiomics of 2-deoxy-2-[F]fluoro-D-glucose ([F]FDG) positron emission tomography (PET)/x-ray computed tomography (CT) in patients with colorectal cancer (CRC).
PROCEDURES
This study included 74 CRC patients who had undergone preoperative [F]FDG PET/CT. A total of 65 PET/CT-related features including intensity, volume-based, histogram, and textural features were calculated. High-resolution melting methods were used for genetic mutation analysis.
RESULTS
Genetic mutants were found in 21 KRAS tumors (28 %), 31 TP53 tumors (42 %), and 17 APC tumors (23 %). Tumors with a mutated KRAS had an increased value at the 25th percentile of maximal standardized uptake value (SUV) within their metabolic tumor volume (MTV) (P < .0001; odds ratio [OR] 1.99; 95 % confidence interval [CI] 1.37-2.90) and their contrast from the gray-level cooccurrence matrix (P = .005; OR 1.52; 95 % CI 1.14-2.04). A mutated TP53 was associated with an increased value of short-run low gray-level emphasis derived from the gray-level run length matrix (P = .001; OR 243006.0; 95 % CI 59.2-996,872,313). APC mutants exhibited lower low gray-level zone emphasis derived from the gray-level zone length matrix (P = .006; OR < .0001; 95 % CI 0.000-0.22).
CONCLUSION
PET/CT-derived radiomics can provide supplemental information to determine KRAS, TP53, and APC genetic alterations in CRC.
目的
了解结直肠癌（CRC）患者 2-脱氧-2-[F]氟-D-葡萄糖（[F]FDG）正电子发射断层扫描（PET）/X 射线计算机断层扫描（CT）的基因突变为放射组学之间的关联。
过程
本研究纳入了 74 例接受术前[F]FDG PET/CT 的 CRC 患者。共计算了 65 个与 PET/CT 相关的特征，包括强度、基于体积的、直方图和纹理特征。采用高分辨率熔解方法进行基因突变分析。
结果
21 例 KRAS 肿瘤（28%）、31 例 TP53 肿瘤（42%）和 17 例 APC 肿瘤（23%）发现有基因突变。在代谢肿瘤体积（MTV）内，具有突变 KRAS 的肿瘤的最大标准化摄取值（SUV）的第 25 百分位数的增值更高（P<0.0001；优势比[OR] 1.99；95%置信区间[CI] 1.37-2.90），且其与灰度共生矩阵的对比度更高（P=0.005；OR 1.52；95%CI 1.14-2.04）。TP53 突变与灰度游程长度矩阵中短程低灰度重点的增值相关（P=0.001；OR 243006.0；95%CI 59.2-996872313）。APC 突变表现出灰度区域长度矩阵中低灰度区域重点较低（P=0.006；OR<0.0001；95%CI 0.000-0.22）。
结论
PET/CT 衍生的放射组学可为确定 CRC 中的 KRAS、TP53 和 APC 遗传改变提供补充信息。
Zotero 插件