Shigefuku Ryuta, Watanabe Tsunamasa, Mizukami Takuro, Matsunaga Kotaro, Hattori Nobuhiro, Ehira Takuya, Suzuki Tatsuya, Nakano Hiroyasu, Sato Yoshinori, Matsuo Yasumasa, Nakahara Kazunari, Ikeda Hiroki, Matsumoto Nobuyuki, Tsuda Takashi, Katayama Masafumi, Koizumi Satoshi, Okuse Chiaki, Suzuki Michihiro, Otsubo Takehito, Nakajima Takako Eguchi, Yasuda Hiroshi, Itoh Fumio
Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa, 216-8511, Japan.
Department of Clinical Oncology, St. Marianna University, Kawasaki, Japan.
Clin J Gastroenterol. 2018 Dec;11(6):487-492. doi: 10.1007/s12328-018-0873-1. Epub 2018 Jun 11.
Oxaliplatin, a chemotherapeutic agent for colorectal cancer, has been associated with pathological evidence of sinusoidal endothelial injury in the liver. However, esophagogastric varices are a poorly recognized outcome of oxaliplatin-based chemotherapy. We report a 78-year-old man, whose past history of colon cancer was resection and treatment with mFOLFOX6 for 20 weeks, as adjuvant chemotherapy. After 3.5-year follow-up of the oxaliplatin-based chemotherapy, he was diagnosed with esophageal varices without liver dysfunction, indicating that the hepatotoxicity caused by oxaliplatin could be prolonged after its administration. Patients who have received oxaliplatin-based chemotherapy should be followed up carefully over the long term.
奥沙利铂是一种用于治疗结直肠癌的化疗药物，与肝脏窦状内皮损伤的病理证据有关。然而，食管胃静脉曲张是基于奥沙利铂化疗的一个鲜为人知的结果。我们报告一名78岁男性，他既往有结肠癌病史，接受了手术切除，并接受mFOLFOX6辅助化疗20周。在基于奥沙利铂的化疗进行3.5年随访后，他被诊断为食管静脉曲张但无肝功能障碍，这表明奥沙利铂引起的肝毒性在给药后可能会持续很长时间。接受过基于奥沙利铂化疗的患者应长期进行仔细随访。
