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Zoledronate increases enrichment, activation and expansion of natural killer cells from umbilical cord blood.

作者信息

Ma Zhijie, Wang Yunhong, Kang Huiyan, Wu Xiaoyun

机构信息

Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Center for Tissue Engineering and Technology of Inner Mongolia, Hohhot, Inner Mongolia, China.

出版信息

Hum Cell. 2018 Oct;31(4):310-312. doi: 10.1007/s13577-018-0213-2. Epub 2018 Jun 13.

DOI:10.1007/s13577-018-0213-2
PMID:29948879
Abstract
摘要

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Zoledronate increases enrichment, activation and expansion of natural killer cells from umbilical cord blood.唑来膦酸可增强脐带血中自然杀伤细胞的富集、活化及扩增。
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2
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3
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Lower concentrations of methyl-β-cyclodextrin combined with interleukin-2 can preferentially induce activation and proliferation of natural killer cells in human peripheral blood.低浓度的甲基-β-环糊精与白细胞介素-2 联合使用，可以优先诱导人外周血中自然杀伤细胞的活化和增殖。
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Case Report: Cord blood-derived natural killer cells as new potential immunotherapy drug for solid tumor: a case study for endometrial cancer.病例报告：脐带血来源的自然杀伤细胞作为治疗实体瘤的新型潜在免疫治疗药物：子宫内膜癌病例研究。
Front Immunol. 2023 Jun 30;14:1213161. doi: 10.3389/fimmu.2023.1213161. eCollection 2023.
2
A simple method for in vitro preparation of natural killer cells from cord blood.从脐血中体外制备自然杀伤细胞的简单方法。
BMC Biotechnol. 2019 Nov 21;19(1):80. doi: 10.1186/s12896-019-0564-0.

本文引用的文献

1
Expansion of Gammadelta T Cells from Cord Blood: A Therapeutical Possibility.从脐带血中扩增γδ T细胞：一种治疗可能性。
Stem Cells Int. 2018 Mar 7;2018:8529104. doi: 10.1155/2018/8529104. eCollection 2018.
2
Expanded and armed natural killer cells for cancer treatment.用于癌症治疗的扩增并武装的自然杀伤细胞。
Cytotherapy. 2016 Nov;18(11):1422-1434. doi: 10.1016/j.jcyt.2016.06.013. Epub 2016 Aug 3.
3
Cord Blood as a Source of Natural Killer Cells.脐带血作为自然杀伤细胞的来源。
Front Med (Lausanne). 2016 Jan 5;2:93. doi: 10.3389/fmed.2015.00093. eCollection 2015.
4
Umbilical cord blood-derived cellular products for cancer immunotherapy.用于癌症免疫治疗的脐带血来源细胞产品。
Cytotherapy. 2015 Jun;17(6):739-748. doi: 10.1016/j.jcyt.2015.03.005. Epub 2015 Mar 18.
5
γδ T Cell Immunotherapy-A Review.γδ T 细胞免疫疗法综述。
Pharmaceuticals (Basel). 2015 Feb 12;8(1):40-61. doi: 10.3390/ph8010040.
6
Cord blood: a promising source of allogeneic natural killer cells for immunotherapy.脐带血：一种用于免疫治疗的有前景的异基因自然杀伤细胞来源。
Cytotherapy. 2015 Jan;17(1):1-2. doi: 10.1016/j.jcyt.2014.12.001.
7
Differential activation of cord blood and peripheral blood natural killer cells by cytokines.细胞因子对脐血和外周血自然杀伤细胞的差异激活作用。
Cytotherapy. 2015 Jan;17(1):73-85. doi: 10.1016/j.jcyt.2014.08.003. Epub 2014 Sep 22.
8
The unique profile of cord blood natural killer cells balances incomplete maturation and effective killing function upon activation.脐血自然杀伤细胞的独特特征在于其在激活时表现出不完全成熟和有效杀伤功能之间的平衡。
Hum Immunol. 2012 Mar;73(3):248-57. doi: 10.1016/j.humimm.2011.12.015. Epub 2011 Dec 28.
9
Cord blood natural killer cells exhibit impaired lytic immunological synapse formation that is reversed with IL-2 exvivo expansion.脐带血自然杀伤细胞表现出裂解免疫突触形成受损，经 IL-2 体外扩增可逆转。
J Immunother. 2010 Sep;33(7):684-96. doi: 10.1097/CJI.0b013e3181e475e9.
10
Zoledronate facilitates large-scale ex vivo expansion of functional gammadelta T cells from cancer patients for use in adoptive immunotherapy.唑来膦酸有助于从癌症患者体内大规模离体扩增功能性γδ T细胞，用于过继性免疫治疗。
Cytotherapy. 2008;10(8):842-56. doi: 10.1080/14653240802419328.