Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Department of Family Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
PLoS One. 2018 Jun 27;13(6):e0199920. doi: 10.1371/journal.pone.0199920. eCollection 2018.
Chronic kidney disease has become an increasingly significant clinical and public health issue, accounting for 1.1 million deaths worldwide. Information on the epidemiology of chronic kidney disease and associated risk factors is limited in the United Arab Emirates. Therefore, this study aimed to evaluate the incidence and causes of chronic kidney disease stages 3-5 in adult United Arab Emirates nationals with or at high risk of cardiovascular disease. This retrospective study included 491 adults with or at high risk of cardiovascular disease (diabetes mellitus or associated clinical disease) who attended outpatient clinics at a tertiary care hospital in Al-Ain, United Arab Emirates. Estimated glomerular filtration rate was assessed every 3 months from baseline to June 30, 2017. Chronic kidney disease stages 3-5 were defined as an estimated glomerular filtration rate < 60 mL/min/1.73 m2 for ≥ 3 months. Multivariable Cox's proportional hazards analysis was used to determine the independent risk factors associated with developing chronic kidney disease stages 3-5. The cumulative incidence of chronic kidney disease stages 3-5 over a 9-year period was 11.4% (95% confidence interval 8.6, 14.0). The incidence rate of these disease stages was 164.8 (95% confidence interval 121.6, 207.9) per 10,000 person-years. The independent risk factors for developing chronic kidney disease stages 3-5 were older age, history of coronary heart disease, history of diabetes mellitus, and history of smoking. These data may be useful to develop effective strategies to prevent chronic kidney disease development in high-risk United Arab Emirates nationals.
慢性肾脏病已成为一个日益严重的临床和公共卫生问题，在全球范围内导致 110 万人死亡。阿联酋的慢性肾脏病流行病学和相关危险因素信息有限。因此，本研究旨在评估有或高心血管疾病风险的成年阿联酋国民中慢性肾脏病 3-5 期的发病率和病因。本回顾性研究纳入了 491 名有或高心血管疾病风险（糖尿病或相关临床疾病）的成年人，他们在阿联酋艾因的一家三级保健医院的门诊就诊。从基线到 2017 年 6 月 30 日，每 3 个月评估一次估算肾小球滤过率。慢性肾脏病 3-5 期定义为估算肾小球滤过率<60ml/min/1.73m2≥3 个月。采用多变量 Cox 比例风险分析确定与发展为慢性肾脏病 3-5 期相关的独立危险因素。9 年内慢性肾脏病 3-5 期的累积发病率为 11.4%（95%置信区间 8.6，14.0）。这些疾病阶段的发病率为 164.8（95%置信区间 121.6，207.9）/10000 人年。发展为慢性肾脏病 3-5 期的独立危险因素为年龄较大、冠心病史、糖尿病史和吸烟史。这些数据可能有助于制定有效的策略，预防高风险阿联酋国民的慢性肾脏病发展。
