长链非编码 RNA H19 通过抑制 miR-196b 促进肺癌的进展。
LncRNA H19-elevated LIN28B promotes lung cancer progression through sequestering miR-196b.
机构信息
a Department of Respiratory medicine , the Second Hospital of Jilin University , Changchun , P.R. China.
b Department of Ophthalmology , the Second Hospital of Jilin University , Changchun , P.R. China.
出版信息
Cell Cycle. 2018;17(11):1372-1380. doi: 10.1080/15384101.2018.1482137. Epub 2018 Jul 23.
Abstract
LncRNA H19 is involved in the development of multiple cancers. Here, we firstly provide new evidence that H19 can induce LIN28B, a conserved RNA binding protein, to accelerate lung cancer growth through sponging miR-196b. Abundance in LIN28B was observed in clinical lung cancer samples. A positive link was observed between H19 and LIN28B in clinical lung cancer samples. In lung cancer cells, H19 was capable of increasing LIN28B expression. Mechanistically, miR-196b directly targeted LIN28B to inhibit LIN28B expression. H19 was capable of promoting LIN28B expression through sequestering miR-196b. Functionally, H19-increased LIN28B conferred the cell proliferation of lung cancer. Our finding indicates that H19 depresses miR-196b to elevate LIN28B, resulting in accelerating cell proliferation in lung cancer.
摘要
LncRNA H19 参与多种癌症的发生发展。在这里，我们首次提供新证据表明，H19 可以通过海绵吸附 miR-196b 来诱导 LIN28B，一种保守的 RNA 结合蛋白，从而加速肺癌的生长。LIN28B 在临床肺癌样本中含量丰富。在临床肺癌样本中观察到 H19 与 LIN28B 之间存在正相关。在肺癌细胞中，H19 能够增加 LIN28B 的表达。从机制上讲，miR-196b 直接靶向 LIN28B 抑制 LIN28B 表达。H19 能够通过结合 miR-196b 来促进 LIN28B 的表达。功能上，H19 增加的 LIN28B 赋予了肺癌细胞的增殖能力。我们的发现表明，H19 抑制 miR-196b 以升高 LIN28B，从而加速肺癌细胞的增殖。
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