Wu Xiao-Ying, Shi Ju-Mei, Tao Yi, Li Zhong
The Tenth People's Hospital of Tongji University, Shanghai 200072, China; Shanghai Armed Police Hospital, Shanghai 201103, China.
The Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Jun;26(3):802-806. doi: 10.7534/j.issn.1009-2137.2018.03.028.
To investigate the diagnostic value of insulin like growth factor I(IGF-I), β2-microglobulin (β2MG) and serum ferritin (SF) in patients with multiple myeloma (MM) and their ralationship with clinical staging.
Seventy-seven patients with MM treated in Depertment of Hematology of Shanghai 10th hospital and Oncology of Shanghai Armed Police Hospital from August 2016 to June 2017 were enrolled in MM group, at same period 77 healthy volunteers were enrolled in normal control group. The diagnostic value of IGF-I, β2-MG and SF for MM, and their levels in different stages of MM were compared.
The ROC analysis showed that β2-MG and SF alone as well as their combination had the diagnostic significance for MM, moreover the diagnostic value of IGF-I, β2-MG and SF combination was highest, but the single IGF-I did not possess diagnostic significance for MM. The comparison of IGF-I, β2-MG and SF levels in different stages of MM showed that the β2-MG and SF levels in I stage were higher than those in normal control group (P<0.05), but lower than those in II and III stages (P<0.05). The IGF-I level in I stage was not statistically and significantly different from IGF-I level in normal control group (P>0.05), but lower than those in II and III stage (P<0.05). The relationship analysis between IGF-I and β2-MG, SF in different stages showed that the IGF-I related with SF in I stage (r=0.417), but did not relate with β2-MG; the IGF-I in II stage related with β2-MG and SF in II stage (r=0.543, r=0.426); IGF-I related with β2-MG and SF in III stage (r=0.425 and r=0.672).
The diagnostic value of IGF-I, β2-MG and SF alone does not high for MM, but their combination can significantly enhance the occurate rate of MM diagnosis. The levels of IGF-I, β2-MG and SF in II and III stages of MM all increase, moreover the level of IGF-I correlates with the levels of β2-MG and SF.
探讨胰岛素样生长因子I（IGF-I）、β2-微球蛋白（β2MG）及血清铁蛋白（SF）在多发性骨髓瘤（MM）患者中的诊断价值及其与临床分期的关系。
选取2016年8月至2017年6月在上海市第十人民医院血液科及上海武警医院肿瘤科治疗的77例MM患者作为MM组，同期选取77例健康志愿者作为正常对照组。比较IGF-I、β2-MG及SF对MM的诊断价值及其在MM不同分期中的水平。
ROC分析显示，单独的β2-MG和SF以及它们的联合检测对MM均有诊断意义，而且IGF-I、β2-MG和SF联合检测的诊断价值最高，但单独的IGF-I对MM无诊断意义。MM不同分期的IGF-I、β2-MG和SF水平比较显示，I期的β2-MG和SF水平高于正常对照组（P<0.05），但低于II期和III期（P<0.05）。I期的IGF-I水平与正常对照组的IGF-I水平无统计学差异（P>0.05），但低于II期和III期（P<0.05）。不同分期IGF-I与β2-MG、SF的相关性分析显示，I期IGF-I与SF相关（r=0.417），但与β2-MG无关；II期IGF-I与II期β2-MG和SF相关（r=0.543，r=0.426）；III期IGF-I与β2-MG和SF相关（r=0.425和r=0.672）。
IGF-I、β2-MG和SF单独对MM的诊断价值不高，但它们的联合检测可显著提高MM诊断的准确率。MM II期和III期的IGF-I、β2-MG和SF水平均升高，而且IGF-I水平与β2-MG和SF水平相关。
