Wang Si-Ying, Qiu Dong-Biao, Fan Cui-Hua
Department of Blood Transfusion, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China.
Department of Blood Transfusion, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China.E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2023 Jun;31(3):788-793. doi: 10.19746/j.cnki.issn.1009-2137.2023.03.025.
To investigate the correlation between serum interleukin-33 (IL-33), βmicroglobulin (β-MG) levels and Durie-Salmon (DS) stage in patients with multiple myeloma (MM).
100 MM patients admitted to the First Affiliated Hospital of Fujian Medical University from March 2019 to January 2021 were selected and divided into stage I, stage II and stage III groups according to the DS staging system. A baseline data questionnaire of patients was designed, then the relevant baseline data and laboratory test results of patients were recorded. The levels of serum IL-33 and β-MG of all patients were detected, and the correlation between serum IL-33, β-MG levels and DS stage of MM patients was analyzed.
Among the 100 patients with MM, there were 32 cases in stage I, 39 cases in stage II and 29 cases in stage III. The levels of serum CRP and β-MG of patients in stage III were significantly higher than those of patients in stage I and II, and the levels of serum CRP and β-MG of patients in stage II were significantly higher than those of patients in stage I, the differences were statistically significant ( <0.05). The level of serum IL-33 of patients in stage III was significantly lower than that of patients in stage I and II, and the level of serum IL-33 of patients in stage II was significantly lower than that of patients in stage I, the differences were statistically significant ( <0.05). There was no statistical significant difference in other data between groups ( >0.05). Kendall's tau-b correlation analysis showed that the levels of serum CRP and β-MG were positively correlated with DS stage in MM patients ( =0.534, 0.776), the level of serum IL-33 was negatively correlated with DS stage in MM patients ( =-0.759). Ordered logistic regression analysis and forest plot showed that the low level of serum IL-33 and the high level of β-MG were the influencing factors of high DS stage in MM patients ( <0.05 ).
DS stage of MM patients is closely related to the levels of serum IL-33 and β-MG, that is, the lower the serum IL-33 level and the higher the β-MG level, and the higher the DS stage of MM patients.
探讨多发性骨髓瘤（MM）患者血清白细胞介素-33（IL-33）、β微球蛋白（β-MG）水平与Durie-Salmon（DS）分期的相关性。
选取2019年3月至2021年1月福建医科大学附属第一医院收治的100例MM患者，根据DS分期系统分为Ⅰ期、Ⅱ期和Ⅲ期组。设计患者基线数据调查问卷，记录患者相关基线数据及实验室检查结果。检测所有患者血清IL-33和β-MG水平，分析MM患者血清IL-33、β-MG水平与DS分期的相关性。
100例MM患者中，Ⅰ期32例，Ⅱ期39例，Ⅲ期29例。Ⅲ期患者血清CRP和β-MG水平显著高于Ⅰ期和Ⅱ期患者，Ⅱ期患者血清CRP和β-MG水平显著高于Ⅰ期患者，差异有统计学意义（<0.05）。Ⅲ期患者血清IL-33水平显著低于Ⅰ期和Ⅱ期患者，Ⅱ期患者血清IL-33水平显著低于Ⅰ期患者，差异有统计学意义（<0.05）。组间其他数据差异无统计学意义（>0.05）。Kendall's tau-b相关性分析显示，MM患者血清CRP和β-MG水平与DS分期呈正相关（=0.534，0.776），血清IL-33水平与MM患者DS分期呈负相关（=-0.759）。有序逻辑回归分析及森林图显示，血清IL-33低水平和β-MG高水平是MM患者DS分期高的影响因素（<0.05）。
MM患者的DS分期与血清IL-33和β-MG水平密切相关，即血清IL-33水平越低、β-MG水平越高，MM患者的DS分期越高。
