Ramadhani Pristya, Bramantono Bramantono, Sedana Made Putra
Department of Internal Medicine, Faculty of Medicine Airlangga University - dr. Soetomo Hospital, Surabaya, Indonesia.
Acta Med Indones. 2018 Apr;50(2):151-158.
Progressive multifocal leukoencephalopathy (PML) is a rare but fatal disease leading to severe neurological impairments. PML is a clinical manifestation, which is usually associated with John Cunningham virus (JCV) infection. It is also correlated to malignancies that mainly include hematologic malignancies such as chronic lymphocytic leukemia (CLL). Until now, no specific treatment has been established for JCV-induced PML; therefore, the prognosis of this disease is poor.We present a case of a 67-year-old woman who suffered from CLL with a chief complaint of seizure. Her clinical symptoms, results of brain MRI and biopsy were suggestive for the JCV-induced PML. The patient had received treatment using mefloquine at dose of 250 mg/day with no clinical improvement.
进行性多灶性白质脑病（PML）是一种罕见但致命的疾病，可导致严重的神经功能障碍。PML是一种临床表现，通常与约翰·坎宁安病毒（JCV）感染有关。它还与主要包括血液系统恶性肿瘤（如慢性淋巴细胞白血病（CLL））的恶性肿瘤相关。到目前为止，尚未确立针对JCV诱导的PML的特异性治疗方法；因此，这种疾病的预后很差。我们报告一例67岁女性患者，她患有CLL，主要症状为癫痫发作。她的临床症状、脑部MRI结果和活检提示为JCV诱导的PML。该患者接受了每天250毫克剂量的甲氟喹治疗，但临床症状无改善。
