Murri Michael S, Moshirfar Majid, Birdsong Orry C, Ronquillo Yasmyne C, Ding Yanning, Hoopes Phillip C
John A Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA.
HDR Research Center, Hoopes Vision, Draper, UT, USA.
Clin Ophthalmol. 2018 Jun 18;12:1105-1112. doi: 10.2147/OPTH.S165553. eCollection 2018.
The amniotic membrane (AM) has a long history of use in the treatment of various diseases of the ocular surface. It contains pluripotent cells, highly organized collagen, anti-fibrotic and anti-inflammatory cytokines, immune-modulators, growth factors, and matrix proteins. It is used to promote corneal healing in severely damaged eyes. Recently, AM extract and AM extract eye drops have been successfully used in clinical applications, including dry eye and chemical burns. We provide an overview on the recent progress in the preparation, mechanisms of action, and use of AM extract/AM extract eye drops for corneal and external eye diseases.
羊膜在治疗各种眼表疾病方面有着悠久的应用历史。它含有多能细胞、高度有序的胶原蛋白、抗纤维化和抗炎细胞因子、免疫调节剂、生长因子以及基质蛋白。它被用于促进严重受损眼睛的角膜愈合。最近，羊膜提取物和羊膜提取物滴眼液已成功应用于临床，包括干眼症和化学烧伤。我们概述了羊膜提取物/羊膜提取物滴眼液在角膜和外眼疾病的制备、作用机制及应用方面的最新进展。
