Cheng Anny M S, Chua Lorraine, Casas Victoria, Tseng Scheffer C G
Ocular Surface Center, Miami, FL, USA.
Research and Development Department, TissueTech, Inc., Miami, FL, USA.
Transl Vis Sci Technol. 2016 May 18;5(3):9. doi: 10.1167/tvst.5.3.9. eCollection 2016 May.
To evaluate the clinical efficacy of morselized amniotic membrane and umbilical cord tissue (MAU) in treating refractory corneal epithelial defect in ocular cicatricial diseases.
Retrospective review of four patients with ocular cicatricial diseases treated with topical MAU for corneal epithelial defects refractory to conventional treatments including topical lubricants, autologous serum, bandage contact lens, and tarsorraphy. Their symptoms, corneal staining, conjunctival inflammation, and visual acuity were compared before and after treatment.
After topical application of MAU twice daily, two patients demonstrated rapid corneal epithelialization with prompt visual acuity improvement at the first day. All patients showed corneal epithelialization in 7.3 ± 2.6 days accompanied by a significant relief of symptoms, reduction of ocular surface inflammation, and improvement of visual acuity.
This pilot study suggests topical MAU can be developed into a novel treatment for treating refractory corneal epithelial defects.
Topical MAU can be an effective novel treatment for refractory corneal epithelial defects.
评估碎化羊膜和脐带组织（MAU）治疗眼瘢痕性疾病中难治性角膜上皮缺损的临床疗效。
回顾性分析4例眼瘢痕性疾病患者，这些患者因角膜上皮缺损对包括局部润滑剂、自体血清、绷带式隐形眼镜和睑裂缝合术在内的传统治疗无效，而接受局部应用MAU治疗。比较治疗前后患者的症状、角膜染色、结膜炎症和视力。
每天局部应用MAU两次后，2例患者在第一天角膜上皮迅速愈合，视力迅速改善。所有患者在7.3±2.6天内角膜上皮愈合，同时症状明显缓解，眼表炎症减轻，视力改善。
这项初步研究表明，局部应用MAU可发展成为治疗难治性角膜上皮缺损的一种新疗法。
局部应用MAU可以成为治疗难治性角膜上皮缺损的一种有效新疗法。
