Liu Ting, Wang Yi-An, Zang Qing, Zhong Guo-Qing
School of Material Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China.
Bioinorg Chem Appl. 2018 May 22;2018:8459638. doi: 10.1155/2018/8459638. eCollection 2018.
A Cu(II) complex [Cu(bipy)(HO)(SO)] (bipy = 2,2'-bipyridine) was synthesized by hydrothermal method and characterized structurally by elemental analyses, single crystal X-ray diffraction, infrared spectra, and thermogravimetry and differential scanning calorimetry. The Cu(II) was hexacoordinated by two N atoms from bipy, two O atoms from different sulfate radical anions, and two O atoms from two water molecules, forming a slightly distorted octahedral geometry, and bridged by sulfato groups into polymeric chains. Under the condition of physiological pH, the interaction mechanism between the complex and hsDNA was explored with acridine orange as a fluorescence probe by spectroscopic methods. The binding modes between the complex and hsDNA were the electrostatic and embedded modes.
通过水热法合成了一种铜（II）配合物[Cu(bipy)(HO)(SO)] （bipy = 2,2'-联吡啶），并通过元素分析、单晶X射线衍射、红外光谱、热重分析和差示扫描量热法对其结构进行了表征。铜（II）由联吡啶的两个N原子、不同硫酸根阴离子的两个O原子以及两个水分子的两个O原子六配位，形成略微扭曲的八面体几何构型，并通过硫酸根基团桥联成聚合物链。在生理pH条件下，以吖啶橙为荧光探针，通过光谱方法研究了该配合物与热变性DNA（hsDNA）之间的相互作用机制。该配合物与hsDNA之间的结合模式为静电结合和嵌入结合模式。
