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豚鼠心脏肌膜钠钾镁三磷酸腺苷酶的抑制作用与非相互作用哇巴因受体的同质群体不相符。

Inhibition of sarcolemmal Na, K, Mg ATPase from the guinea pig heart is not compatible with a homogeneous population of non-interacting ouabain receptors.

作者信息

Ebner F, Schönsteiner G

出版信息

Experientia. 1985 Sep 15;41(9):1147-9. doi: 10.1007/BF01951701.

DOI:10.1007/BF01951701
PMID:2995113
Abstract

The inhibition of sarcolemmal Na, K, Mg ATPase from the guinea pig heart by ouabain was evaluated with a coupled enzyme assay. Models of negative cooperativity and of two independent receptors fitted the inhibition data equally well. The analysis was not compatible with a homogeneous population of non-interacting ouabain receptors.

摘要

采用偶联酶分析法评估了哇巴因对豚鼠心脏肌膜钠钾镁ATP酶的抑制作用。负协同性模型和两个独立受体模型对抑制数据的拟合效果同样良好。该分析与非相互作用的哇巴因受体的同质群体不相符。

相似文献

1
Inhibition of sarcolemmal Na, K, Mg ATPase from the guinea pig heart is not compatible with a homogeneous population of non-interacting ouabain receptors.豚鼠心脏肌膜钠钾镁三磷酸腺苷酶的抑制作用与非相互作用哇巴因受体的同质群体不相符。
Experientia. 1985 Sep 15;41(9):1147-9. doi: 10.1007/BF01951701.
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引用本文的文献

1
The reaction of ouabain with the sodium pump of guinea-pig myocardium in relation to its inotropic effect.哇巴因与豚鼠心肌钠泵的反应及其变力作用
J Physiol. 1986 Oct;379:187-203. doi: 10.1113/jphysiol.1986.sp016247.
2
Factors influencing the onset of ouabain inhibition of Na,K-ATPase from guinea-pig myocardium.影响哇巴因抑制豚鼠心肌钠钾ATP酶起始作用的因素。
Br J Pharmacol. 1990 Oct;101(2):337-43. doi: 10.1111/j.1476-5381.1990.tb12711.x.

本文引用的文献

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Two molecular forms of (Na+ + K+)-stimulated ATPase in brain. Separation, and difference in affinity for strophanthidin.脑中（钠+钾）激活的ATP酶的两种分子形式。分离以及对毒毛花苷原亲和力的差异。
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