Sheikhpour Robab, Pourhosseini Fatemeh, Neamatzadeh Hossein, Karimi Roghayeh
Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Biology, Kerman University of Medical Sciences, Kerman, Iran.
Med J Islam Repub Iran. 2017 Dec 23;31:121. doi: 10.14196/mjiri.31.121. eCollection 2017.
Non-Hodgkin's lymphoma (NHLs) is known as a heterogeneous group of malignant lymphoproliferative disorders. NHLs are classified into B cell and T cell types. Immunophenotypical assessment of the biopsy specimens can help diagnose NHLs. In this study, 77 patients with B cell and T cell lymphoma were selected from Shahid Sadoghi hospital during 2010 to 2013. Immunohistochemical method was used to detect biomarkers like CD2, CD3, CD20, and CD45. In this study, 67 patients (87.01 %) had B cell lymphoma. Moreover, the most primary tissues in B cell group were lymph node and stomach, followed by bone marrow and neck. Positive co-expression of CD45 and CD20 was found in 61 patients (91.04%) with B cell lymphoma. However, 10 patients (12.98%) had T cell lymphoma, and the most primary tissue in T cell lymphoma group was the skin. Moreover, CD3 expression was seen in all patients with T cell lymphoma. This study confirmed the main role of immunohistochemistry method in classifying and diagnosing NHLs. Moreover, the difference in CD marker expression and age in patients with B cell and T cell lymphoma, compared to other studies may be due to geographic area and genetic and ethnic differences.
非霍奇金淋巴瘤（NHLs）是一组异质性的恶性淋巴增殖性疾病。NHLs分为B细胞型和T细胞型。对活检标本进行免疫表型评估有助于诊断NHLs。在本研究中，2010年至2013年期间从沙希德·萨多吉医院选取了77例B细胞和T细胞淋巴瘤患者。采用免疫组织化学方法检测CD2、CD3、CD20和CD45等生物标志物。在本研究中，67例患者（87.01%）患有B细胞淋巴瘤。此外，B细胞组中最主要的组织是淋巴结和胃，其次是骨髓和颈部。61例（91.04%）B细胞淋巴瘤患者中发现CD45和CD20呈阳性共表达。然而，10例患者（12.98%）患有T细胞淋巴瘤，T细胞淋巴瘤组中最主要的组织是皮肤。此外，所有T细胞淋巴瘤患者均可见CD3表达。本研究证实了免疫组织化学方法在NHLs分类和诊断中的主要作用。此外，与其他研究相比，B细胞和T细胞淋巴瘤患者CD标志物表达和年龄的差异可能归因于地理区域以及遗传和种族差异。
